Ludwig Mies van der Rohe, famously said of architecture that “Less is more”. This principle is based on the idea that removing superfluous elements enhances the clarity of the concept. It emphasizes functionality, clean aesthetics and simplicity. The German pavilion that he designed for the… Read More »Aptamer architecture: Less is more in truncations
In the dynamic realm of molecular biology, the quest for enhancing diagnostic tools and therapeutic approaches is an ever-evolving journey. One significant breakthrough in this pursuit is the development of the Neomer library, an innovative platform that allows the utilization of identical sequences across various… Read More »Unleashing the Potential of Neomer Library: A Revolutionary Approach to Aptamer Characterization and Improvement
Revolutionary Biomarker Discovery: Aptamarker allows agnostic screening for biomarkers, transforming disease understanding. Enables patient stratification in clinical trials for enhanced safety and precision medicine. Predictive and Precise Drug Development: Predicts side effects and translates animal model findings for safer drug development. Maps drug binding sites… Read More »Unleashing the Power of Aptamarkers: A New Frontier in Disease Management
NeoVentures’ Neomer aptamer selection method replaces the traditional SELEX process, offering a closed and reproducible space for aptamer development, ensuring consistency in drug level detection. The inclusion of an in-silico immune tolerance step enhances Neomer aptamers’ specificity and selectivity, making them more precise in detecting… Read More »Revolutionizing Drug Level Detection: NeoVentures’ Neomer Aptamers Take the Lead
Immune Tolerance Advantage of Aptamarkers: Aptamarkers overcome immune tolerance issues in traditional antibody development. Aptamarkers vs. Antibodies: A Quantitative Advantage: Broader recognition spectrum aligns the biomarker landscape in animal models more closely with the human context. Training Aptamarkers in Animal Trials: Aptamarkers can be trained… Read More »Aptamarker Use Case: Breaking Barriers – Aptamarkers Pave the Way for Seamless Translation from Animal Trials to Human Trials
NeoVentures Biotechnology’s Aptamarker platform revolutionizes clinical trials by introducing personalized and predictive inclusion and exclusion criteria. Aptamarkers are trained using biological samples and participants’ treatment responses, enabling a cost-effective qPCR test for screening individuals entering clinical trials. The predictive capabilities of Aptamarkers allow researchers to… Read More »Aptamarker Use Case: Enhancing Clinical Trials with Aptamarker Precision – Tailoring Inclusion and Exclusion Criteria
In the rapidly advancing field of molecular medicine, researchers are constantly on the lookout for innovative therapies that can target specific disease molecules with precision and efficacy. Aptamers, a class of synthetic oligonucleotides, have emerged as a promising and versatile tool in the quest for… Read More »Aptamers: A Novel Therapeutic Oligonucleotide
Aptamers are engineered molecules that can bind to specific target compounds with high affinity and selectivity, making them valuable tools in various applications. Achieving absolute specificity, or binding to a single compound exclusively, is challenging due to the structural similarities among molecules. However, aptamers can… Read More »The Specificity of Aptamers: Can They Selectively Bind to a Single Compound?
In the realm of modern medicine, researchers and scientists are continually exploring innovative ways to combat diseases and improve the quality of life for patients. Two emerging contenders in the therapeutic arena are antibodies and aptamers. These molecular warriors hold immense potential in diagnosing and… Read More »A Therapeutic Battle: Antibodies vs. Aptamers
One of the most remarkable aspects of the integration of aptamers with qPCR for protein detection is the unprecedented sensitivity it brings to the table. Traditional protein detection methods, such as ELISA and Western blotting, often struggle to accurately quantify proteins present in very low… Read More »Advancements in Sensitivity: qPCR’s Remarkable Detection of Proteins
We are pleased to announce that our European subsidiary company, NeoNeuro has recently succeeded with a pre-clinical trial of their blood test for brain amyloid with the collaboration of the Centro Hospitalar de Entre o Douro e Vouga, in Santa Maria da Fiera, Portugal. This… Read More »Successful Pre-clinical Trial of Aptamer-based Blood Test for Alzheimer’s Disease
Welcome to the forefront of scientific exploration, where the power of aptamers is reshaping the boundaries of medicine, diagnostics, and beyond. The aptamer frontier represents a captivating realm of discovery, where researchers and innovators are unlocking previously unimaginable applications and uncharted possibilities. In this blog,… Read More »The Aptamer Frontier: Discovering New Applications and Possibilities
Aptamers, versatile nucleic acid molecules with tremendous potential for targeted therapies and diagnostics, have gained significant attention in recent years. We are among the key players in this exciting field, known for our leadership in aptamer patenting. With employees named on 85 published patent applications… Read More »Innovating the Landscape of Aptamer Intellectual Property: A Look Inside NeoVentures and NeoNeuro
In recent years, the field of therapeutics has witnessed remarkable advancements in the development of novel treatment strategies. Among the emerging approaches, aptamers have emerged as powerful tools with immense potential in various therapeutic applications. Aptamers, short single-stranded nucleic acid or peptide molecules, can specifically… Read More »Unlocking Therapeutic Potential: Aptamers as Promising Tools in Medicine
Aptamer-based biosensors typically consist of three components: the aptamer as the recognition element, a transducer, and a signal output. The aptamer binds to the target molecule, and this binding event is then transduced into a detectable signal by the transducer. The signal output can be… Read More »What Are Aptamer-Based Biosensors & Their Applications?
In the world of molecular recognition and targeted therapies, aptamers have emerged as an alternative to antibodies. These nucleic acid molecules possess a remarkable set of characteristics that make them highly desirable in various fields, including diagnostics, therapeutics, and drug development. Aptamers exhibit exceptional specificity… Read More »Unleashing the Power of Aptamers: A Versatile Alternative to Antibodies
NeoVentures was formed as an aptamer development company in June of 2002, and founded on a very simple principle. Businesses that create real sustainable value for their clients succeed. This does not always seem to be case as we have all seen biotechnology companies that… Read More »Why has NeoVentures succeeded as an Aptamer development company?
We recently asked which of the following applications cannot be done with aptamers? The results were overwhelmingly in favor of one choice: We can go through each option to see how aptamers are indeed able to be used in diagnostics, therapeutics, and drug discovery but… Read More »What Cannot Be Done with Aptamers?
NeoVentures is pleased to announce the successful completion of a project with a Fortune 500 pharmaceutical company resulting in the development of aptamers as tools for high throughput biomanufacturing of drugs. The key advantage of aptamers in this type of application is the capacity to… Read More »Aptamers for Biomanufacturing of Drugs
In our “What is an aptamer” blog, we described that aptamers are synthetically made, single-stranded DNA or RNA molecules. There are inherent differences between DNA and RNA when found naturally. DNA is typically a double-stranded biomolecule composed of A, T, C, and G bases. RNA… Read More »DNA vs RNA Aptamers
Currently, at NeoVentures, we believe that there is no concrete answer to the question if aptamers are better than antibodies. We have thoughts on why aptamers would be more useful in specific cases, but there just isn’t the same amount of literature available yet on… Read More »Are Aptamers Better than Antibodies?
Aptamers are selected from large libraries of random sequences, thus aptamers themselves are not designed but the libraries that they are selected from are. The standard method of aptamer design has been for SELEX selection. This involves a synthetic library with a random region flanked… Read More »Aptamer Libraries – What is Neomers?
We thought that the World Cup was a timely icon for this blog series. This will be a blog series because there are so many reasons why we are the best aptamer company. What are they? You own the aptamers, no royalties. Innovative NEOMER aptamer… Read More »Why is NeoVentures the Best Aptamer Company for Your Needs?
What determines the binding capacity of an aptamer? Our poll results indicate that……… Nature of the target The peptide bond Nucleotide staking free energy Van der Waals forces Let’s go through the options one by one to determine the correct answer. b) The Peptide Bond. It… Read More »What Determines the Binding Capacity of an Aptamer?
Antibody Binding vs. Aptamer Binding The immune system has developed very effective screening methods for eliminating antibodies that bind even weakly to self targets such as serum albumin and IgG. Aptamer selection is done outside the body, on the bench which provides many advantages but implicit… Read More »How We Avoid Self-Recognition with Aptamers
Did you see our poll on LinkedIn? If not, check it out here! Our answer to this poll will be short and sweet: Sugars are molecules that have a generic formula of CnH2nOn. They can be described as polyhydroxy compounds containing one ether bond. Most… Read More »Can Aptamers Bind to Sugar Molecules?
The use of the traditional SELEX method for aptamer development has led to the identification of aptamers that bind to a wide diversity of targets. However, there has been limited success with aptamers in therapeutic and diagnostic applications. A key advantage of aptamer development over… Read More »Announcing The Future of Aptamers: Neomers
The clear winner of our poll on antibody specificity was that antibodies have evolved to ignore HAS/IgG. I struggle with this, as I think it is too simple. Really, the way that antibodies rearrange to detect foreign antigens is open; there are no barriers to… Read More »Why Do Antibodies Perform Better in Matrices than Aptamers?
The aptamer market has been growing steadily as there has been increasing awareness of the advantages of aptamers in diagnostic and therapeutic platforms. It has been reported that the global aptamer marker has been forecasted to at least double in value over the next 5… Read More »The Aptamer Market
The shape of an aptamer is very important for its binding affinity to the target. This is because the shape allows it to ‘fit’ into a target, but also orients the nucleotides involved in binding in a way that optimizes binding interactions. For aptamers to… Read More »Aptamer Design
Finding a diagnostic reagent that is right for a point-of-care application can be tricky due to the long list of obstacles that need to be overcome. The reagent needs to be shelf-stable, give reproducibly sensitive and selective results, be easy to synthesize, and most importantly,… Read More »What is An Aptamer?
In this blog series we will provide a comprehensive review of how aptamers work by comparing and contrasting them with antibodies. We consider antibodies to be equivalent to aliens and aptamers are our heroes, the cowboys, and of course we all know that the cowboys… Read More »How do Aptamers and Antibodies Work?
The relationship between structure and function is pretty obvious in a lot of engineering projects. Clearly the same is true for aptamers. The functionality of an aptamer is based entirely on it’s structure. In this series of blogs we are going to reveal how we… Read More »Aptamer Structure Prediction
I love the confidence of those responding. Basically the winning category was that aptamers work great, they just have not been tried in enough applications. In my opinion, we should have provided a fifth option in this poll, All of the above… Successful monoclonal antibody… Read More »Why Have Aptamers Not Been More Successful in Therapeutics?
Thanks to all who participated in our poll on why aptamers have not been commercialized in diagnostic applications. The most popular response was platforms are designed for antibodies. I will avoid commenting on the vested interest of the Illuminati because I do not want to… Read More »Why Have Aptamers Not Been Commercialized in Diagnostic Applications?
This is the first of several blogs we will share on our new Neomer process. The image above can be compared to a dilemma in traditional aptamer selection: are the aptamers that are enriching the product of the selection process (I would vote for the… Read More »How We Overcome Process Bias with Neomers
Fabergé made the egg above on commission for Dr. Emanuel Nobel, nephew of Alfred Nobel. The surprise inside is a diamond encrusted platinum and rock crystal watch. The enduring value of Fabergé eggs is due to their beauty and the painstaking craftmanship of their production. … Read More »Custom Aptamers
SELEX has been the basic method for identifying aptamers for the last thirty years. It is time for an improvement. The key constraint implicit in the SELEX method is that it is not reproducible. Every time a new starting library is selected from a synthesized… Read More »The Neomer Selection Strategy – A Game Changing Innovation From NeoVentures.
The phoenix of mythology arises from the ashes of its predecessor. This seems like a very intriguing phenomena, but strikes me as difficult to control in a commercial application. Yet, we keep getting asked whether this is necessary for aptamers to work. Do aptamers need… Read More »Why We Avoid Denaturation of Aptamers for Commercial Applications
Electrical impedance spectroscopy is an approach to measuring the modulation of the surface of an electrode as a result of the binding of a target molecule with an aptamer without labeling the aptamer with a redox moiety such as methylene blue. In this approach we… Read More »Electrochemistry and Aptamers IV
Square waves happen in the ocean when waves in different directions cross each other. They are beautiful but dangerous for swimmers. Square wave voltammetry is similar but I think definitely less dangerous. I will use an incomprehensible introductory sentence and then deconstruct this in order… Read More »Square Wave Voltammetry (SWV) Used in Diagnostic Applications with Aptamers
Nostradamus famously predicted many world events. I have searched for his insights on aptamers, but have come up empty. Therefore, I have realized that it falls upon us to make predictions for aptamers for 2022. There will be more than one aptamer approved by the… Read More »New Year’s Predictions
NeoVentures has upgraded their next generation sequence (NGS) from Illumina HiSeq to NovaSeq. Why is this important to you? Aptamers that will enable commercial applications in diagnostics and therapeutics have to be optimal in terms of sensitivity and specificity. The best aptamers in terms of… Read More »NeoVentures Announcement!!!
Custom design of an aptamer selection strategy that will fit your needs. This means appropriate counter selection, appropriate matrix selection, and appropriate target identification. Guidance of the selection process to ensure appropriate balance between specificity and affinity. At NeoVentures we support this by mathematically modeling… Read More »Custom Aptamers “7 steps for aptamers to be applied commercially”
In our previous post on “can aptamers replace antibodies” we mentioned some of the limitations where antibodies are unable to detect small molecules. Today we would be discussing the limitations of antibodies in Viral infections. Despite years of research, certain pathogens, such as HIV, have… Read More »Can aptamers replace antibodies ?“Neutralization of infections”
NeoVentures does not have a catalog for aptamers nor sell a pre-set aptamer development package. Your journey with us starts with our understanding of your needs for aptamer performance. We use this to develop a customized strategy for every aspect of project development from identifying… Read More »How To Buy Aptamers ?
Advantages Of Aptamers Over Antibodies For diagnosis of viral infection aptamers are clearly the preferred choice over antibodies in the developing world where the need for consistent refrigeration may pose a problem. We have been able to achieve the necessary levels of sensitivity with aptamers… Read More »Aptamers Vs Antibodies
“A person is a person no matter how small” Dr. Seuss in Horton’s Hears a Who I am not sure how well distributed Dr. Seuss books are outside of North America. They were a staple of my childhood, and I made sure that they were… Read More »The Advantage of shorter Aptamers
The picture above is of Robert Pirsig, author of Zen and the Art of Motorcycle Maintenance. This book had a profound impact on me. He articulates the thought that a high level of engagement is necessary for excellence, and that this is also the key… Read More »Aptamer commercialization IV
Skoll is the name of the wolf, Who follows the shining priest, Into the desolate forest, And the other is Hati, Hróðvitnir’s son, Who chases the bright bride of the sky Snorri Sturluson’s Grímnismál I chose Norse mythology as a description of the cause of solar… Read More »Aptamer Chemistry Series IV: Fluorescence and Aptamers
Bernard Trevisan ,an unfortunately fictional character, is attributed with spending his life in the scientific pursuit of the Philospher’s Stone, a substance that could transform a base metal into gold. Although Bernard was not ultimately successful, he represents all of those alchemists who built the… Read More »Aptamer Chemistry : The Philosopher’s Stone
Robert Frost’s poem, “Two roads diverged in a yellow wood, … I took the one less traveled by,. And that has made all the difference …” may be useful advice for life, but not when preparing a path for new products that will be subject to regulatory approval. Developing new… Read More »Modified Nucleotides: Follow the Vaccines
“The universe (which others call the Library) is composed of an indefinite, perhaps infinite number of hexagonal galleries.” ― Jorge Luis Borges, quote from The Library of Babel (https://en.wikipedia.org/wiki/The_Library_of_Babel) A library of aptamers is like a library of books. They both contain strings of information… Read More »FRELEX III: Aptamarkers
In the M.C. Escher painting, “Reptiles” it is clear how much more information is present in the three-dimensional representation of the lizards versus their two-dimensional counterparts. The three-dimensional lizards are alive, they are bending over and interacting with surfaces. I will argue that the situation… Read More »FRELEX: “The concept”
In the ever-evolving field of diagnostics, precision and predictability are key to developing reliable products. However, the traditional reliance on antibodies poses significant challenges due to the inherent uncertainties in measuring their binding affinity and quantity. This creates a complex, two-variable problem that complicates product… Read More »The Aptamer Advantage: Breaking Free from Antibody Uncertainty
In the rapidly evolving field of biotechnology, researchers constantly develop new tools and technologies to address pressing matters. One such technology that has been gaining significant attention is aptamers. These versatile, single-stranded DNA or RNA molecules have the unique ability to bind to specific targets.… Read More »Advantages of Aptamers – Why You Should Know Aptamers!
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