I love the confidence of those responding. Basically the winning category was that aptamers work great, they just have not been tried in enough applications. In my opinion, we should have provided a fifth option in this poll, All of the above… Successful monoclonal antibody… Read More »Why Have Aptamers Not Been More Successful in Therapeutics?
This blog starts with a portrait of Claude Louis Berthollet (1748 – 1872), who was the first to demonstrate and elaborate on the concept of chemical reversibility. As an aside, it should be noted that he accompanied Napoleon to Egypt and, along with Joseph Fourier,… Read More »The Concept of Chemical Reversibility and Implications for Commercial Aptamer Diagnostics
Thanks to all who participated in our poll on why aptamers have not been commercialized in diagnostic applications. The most popular response was platforms are designed for antibodies. I will avoid commenting on the vested interest of the Illuminati because I do not want to… Read More »Why Have Aptamers Not Been Commercialized in Diagnostic Applications?
This is the first of several blogs we will share on our new Neomer process. The image above can be compared to a dilemma in traditional aptamer selection: are the aptamers that are enriching the product of the selection process (I would vote for the… Read More »Advantages of the Neomer Selection Process: Overcoming Process Bias
Fabergé made the egg above on commission for Dr. Emanuel Nobel, nephew of Alfred Nobel. The surprise inside is a diamond encrusted platinum and rock crystal watch. The enduring value of Fabergé eggs is due to their beauty and the painstaking craftmanship of their production. … Read More »Custom Aptamers
SELEX has been the basic method for identifying aptamers for the last thirty years. It is time for an improvement. The key constraint implicit in the SELEX method is that it is not reproducible. Every time a new starting library is selected from a synthesized… Read More »The Neomer Selection Strategy – A Game Changing Innovation From NeoVentures.
The phoenix of mythology arises from the ashes of its predecessor. This seems like a very intriguing phenomena, but strikes me as difficult to control in a commercial application. Yet, we keep getting asked whether this is necessary for aptamers to work. Do aptamers need… Read More »No to Denaturation of Aptamers for Commercial Applications
Scriptorium was a word used in medieval times to describe a place reserved for copying manuscripts. Now, every company developing aptamer based commercial products should define their own scriptorium, even if this refers to an online space. The most important guide for all aspects of… Read More »Commercializing Aptamers: The Importance of SOPs
This blog is the last in this series, for now. This is definitely an area that we will be revisiting soon. The executive summary for this whole series, is that I think that electrochemical detection is definitely the future for aptamer based diagnosis. This is… Read More »Electrochemistry and Aptamer Summary VI
Electrical impedance spectroscopy is an approach to measuring the modulation of the surface of an electrode as a result of the binding of a target molecule with an aptamer without labeling the aptamer with a redox moiety such as methylene blue. In this approach we… Read More »Electrochemistry and Aptamers IV