Electrical impedance spectroscopy is an approach to measuring the modulation of the surface of an electrode as a result of the binding of a target molecule with an aptamer without labeling the aptamer with a redox moiety such as methylene blue. In this approach we… Read More »Electrochemistry and Aptamers IV
In our last blog we discussed the electrical basis for square wave voltammetry. In this blog we will focus on the chemistry part of electrochemical. The powder depicted above is methylene blue (MB). This is a redox agent, meaning that this molecule is an oxidation… Read More »Square Wave Voltammetry ( SWV) and the Blue Dye.
Square waves happen in the ocean when waves in different directions cross each other. They are beautiful but dangerous for swimmers. Square wave voltammetry is similar but I think definitely less dangerous. I will use an incomprehensible introductory sentence and then deconstruct this in order… Read More »Square Wave Voltammetry (SWV) Used in Diagnostic Applications with Aptamers
COVID-19 and an increased public understanding of diagnostics. We have noticed during walks that the majority of conversations that we overhear are related to the pandemic. What is particularly striking is the use of words that pre-pandemic were part of our scientific jargon but not… Read More »The Effect of the Pandemic on Public Understanding of Healthcare
Nostradamus famously predicted many world events. I have searched for his insights on aptamers, but have come up empty. Therefore, I have realized that it falls upon us to make predictions for aptamers for 2022. There will be more than one aptamer approved by the… Read More »New Year’s Predictions
NeoVentures has upgraded their next generation sequence (NGS) from Illumina HiSeq to NovaSeq. Why is this important to you? Aptamers that will enable commercial applications in diagnostics and therapeutics have to be optimal in terms of sensitivity and specificity. The best aptamers in terms of… Read More »NeoVentures Announcement!!!
Custom design of an aptamer selection strategy that will fit your needs. This means appropriate counter selection, appropriate matrix selection, and appropriate target identification. Guidance of the selection process to ensure appropriate balance between specificity and affinity. At NeoVentures we support this by mathematically modeling… Read More »Custom Aptamers “7 steps for aptamers to be applied commercially”
In our previous post on “can aptamers replace antibodies” we mentioned some of the limitations where antibodies are unable to detect small molecules. Today we would be discussing the limitations of antibodies in Viral infections. Despite years of research, certain pathogens, such as HIV, have… Read More »Can aptamers replace antibodies ?“Neutralization of infections”
NeoVentures does not have a catalog for aptamers nor sell a pre-set aptamer development package. Your journey with us starts with our understanding of your needs for aptamer performance. We use this to develop a customized strategy for every aspect of project development from identifying… Read More »How To Buy Aptamers ?
Can aptamers replace antibodies? Almost all existing diagnostic kits are based on the use of an antibody for the target compound. A $17B industry has been built on this basis. However, antibodies have their limitations: Antibodies will not detect small molecules unless the small molecule… Read More »Aptamers Vs Antibodies
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