Fabergé made the egg above on commission for Dr. Emanuel Nobel, nephew of Alfred Nobel. The surprise inside is a diamond encrusted platinum and rock crystal watch. The enduring value of Fabergé eggs is due to their beauty and the painstaking craftmanship of their production. … Read More »Custom Aptamers
SELEX has been the basic method for identifying aptamers for the last thirty years. It is time for an improvement. The key constraint implicit in the SELEX method is that it is not reproducible. Every time a new starting library is selected from a synthesized… Read More »The Neomer Selection Strategy – A Game Changing Innovation From NeoVentures.
The phoenix of mythology arises from the ashes of its predecessor. This seems like a very intriguing phenomena, but strikes me as difficult to control in a commercial application. Yet, we keep getting asked whether this is necessary for aptamers to work. Do aptamers need… Read More »Why We Avoid Denaturation of Aptamers for Commercial Applications
Scriptorium was a word used in medieval times to describe a place reserved for copying manuscripts. Now, every company developing aptamer based commercial products should define their own scriptorium, even if this refers to an online space. The most important guide for all aspects of… Read More »Commercializing Aptamers: The Importance of SOPs
This blog is the last in this series, for now. This is definitely an area that we will be revisiting soon. The executive summary for this whole series, is that I think that electrochemical detection is definitely the future for aptamer based diagnosis. This is… Read More »Electrochemistry and Aptamer Summary VI
Electrical impedance spectroscopy is an approach to measuring the modulation of the surface of an electrode as a result of the binding of a target molecule with an aptamer without labeling the aptamer with a redox moiety such as methylene blue. In this approach we… Read More »Electrochemistry and Aptamers IV
In our last blog we discussed the electrical basis for square wave voltammetry. In this blog we will focus on the chemistry part of electrochemical. The powder depicted above is methylene blue (MB). This is a redox agent, meaning that this molecule is an oxidation… Read More »Square Wave Voltammetry ( SWV) and the Blue Dye.
Square waves happen in the ocean when waves in different directions cross each other. They are beautiful but dangerous for swimmers. Square wave voltammetry is similar but I think definitely less dangerous. I will use an incomprehensible introductory sentence and then deconstruct this in order… Read More »Square Wave Voltammetry (SWV) Used in Diagnostic Applications with Aptamers
COVID-19 and an increased public understanding of diagnostics. We have noticed during walks that the majority of conversations that we overhear are related to the pandemic. What is particularly striking is the use of words that pre-pandemic were part of our scientific jargon but not… Read More »The Effect of the Pandemic on Public Understanding of Healthcare
Nostradamus famously predicted many world events. I have searched for his insights on aptamers, but have come up empty. Therefore, I have realized that it falls upon us to make predictions for aptamers for 2022. There will be more than one aptamer approved by the… Read More »New Year’s Predictions
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