“The definition of insanity is doing the same thing over and over and expecting different results.” Albert Einstein- PART 2 If you’ve been following along with the previous blog post, we explored what had been the constraints for the commercialization of aptamer-based diagnostics. Today, we’re picking… Read More »The Future of Aptamers in Diagnostics -Part II
“The definition of insanity is doing the same thing over and over and expecting different results.” – Albert Einstein The Future of Aptamers in Diagnostics – Part 1 Aptamers have not fulfilled the promise of significantly replacing antibodies as the basis for diagnosis, with very little… Read More »The Future of Aptamers in Diagnostics – Part 1
Reinventing Aptamer Science: The Neomer Platform In 2022, NeoVentures Biotechnology revolutionized aptamer science by introducing reproducibility, paving the way for the next generation of aptamers. Using our neomer platform, we reduced the number of random nucleotides while preserving optimal structural diversity. This innovation addressed the… Read More »The Next Generation of Aptamers
Ludwig Mies van der Rohe, famously said of architecture that “Less is more”. This principle is based on the idea that removing superfluous elements enhances the clarity of the concept. It emphasizes functionality, clean aesthetics and simplicity. The German pavilion that he designed for the… Read More »Aptamer architecture: Less is more in truncations
The Enzyme-Linked Immunosorbent Assay (ELISA) was invented by Swedish scientists Eva Engvall and Peter Perlmann in 1971. This groundbreaking diagnostic method revolutionized medicine by using antibodies to detect the presence of specific hormones or viruses, providing results much faster than traditional methods. The Enzyme-Linked Immunosorbent… Read More »The Enzyme-Linked Oligonucleotide Assay. The aptamer ELISA.
Background: By translating information on protein abundance to information on DNA abundance High-Plex proteomics brings deeper analysis than transcriptomics on a protein level. Pioneers like Olink and Somalogic have been leaders in building a future based on protein abundance. There are, however, weaknesses in the… Read More »The Aptamarker Platform
Keys to solving problems with aptamers: Obtain good specific aptamers We think that the only way to reliably obtain aptamers that will be specific enough for commercial applications is to use our reinvented Neomer library approach. Aptamer quality should be based on scientifically stringent binding… Read More »The NeoVentures’ Business Strategy Part 2
CRO: contract research organization. A company that provides support to the pharmaceutical, biotechnology, and medical device industries in the form of research services outsourced on a contract basis. At NeoVentures, we do not consider ourselves as a (CRO). We approach what we do more as co-entrepreneurs with you. Clients come to… Read More »The NeoVentures’ Business Strategy Part 1
In year three of the French revolution, a law was enacted to realize the rallying cry, “un roi, une loi, un poids, et une mesure” (One king, one law, one weight, and one measure) and this became the introduction of the metric system. The one… Read More »The Importance Of What Is Difficult To Measure: How NeoVentures’ Aptamarker Platform Is Setting New Standards in Protein Measurement
One story embedded in One Thousand and One Nights is the story of Aladdin. A poor boy, that one day outsmarts the evil sorcerer and get hold of the magic lamp. Inside the lamp lives the genie, who will grant him all his wishes. Now,… Read More »Why Antibodies Wish They Could be DNA
In the dynamic realm of molecular biology, the quest for enhancing diagnostic tools and therapeutic approaches is an ever-evolving journey. One significant breakthrough in this pursuit is the development of the Neomer library, an innovative platform that allows the utilization of identical sequences across various… Read More »Unleashing the Potential of Neomer Library: A Revolutionary Approach to Aptamer Characterization and Improvement
Molecular Space Construction: NeoVentures Biotechnology’s Aptamarker platform leverages Aptamarker analysis to construct a molecular space, where individuals cluster based on unique biomolecular profiles. This space captures diversity in responses to diseases and allows for the nuanced exploration of different pathophysiological processes leading to the same… Read More »Aptamarker Use Case: Navigating the Molecular Landscape: Aptamarkers as the Compass for Patient Stratification
Revolutionary Biomarker Discovery: Aptamarker allows agnostic screening for biomarkers, transforming disease understanding. Enables patient stratification in clinical trials for enhanced safety and precision medicine. Predictive and Precise Drug Development: Predicts side effects and translates animal model findings for safer drug development. Maps drug binding sites… Read More »Unleashing the Power of Aptamarkers: A New Frontier in Disease Management
Aptamarker Paradigm Shift: NeoVentures Biotechnology’s Aptamarker platform challenges the traditional approach to biomarker discovery by eliminating the need to first understand the cause of a disease. Revolutionizing Healthcare: Aptamarker enables the identification of disease biomarkers without the constraints of unraveling disease causation, leading to faster… Read More »Revolutionizing Disease Detection: NeoVentures Biotechnology’s Aptamarker Platform
NeoVentures’ Neomer aptamer selection method replaces the traditional SELEX process, offering a closed and reproducible space for aptamer development, ensuring consistency in drug level detection. The inclusion of an in-silico immune tolerance step enhances Neomer aptamers’ specificity and selectivity, making them more precise in detecting… Read More »Revolutionizing Drug Level Detection: NeoVentures’ Neomer Aptamers Take the Lead
Immune Tolerance Advantage of Aptamarkers: Aptamarkers overcome immune tolerance issues in traditional antibody development. Aptamarkers vs. Antibodies: A Quantitative Advantage: Broader recognition spectrum aligns the biomarker landscape in animal models more closely with the human context. Training Aptamarkers in Animal Trials: Aptamarkers can be trained… Read More »Aptamarker Use Case: Breaking Barriers – Aptamarkers Pave the Way for Seamless Translation from Animal Trials to Human Trials
NeoVentures Biotechnology’s Aptamarker platform revolutionizes clinical trials by introducing personalized and predictive inclusion and exclusion criteria. Aptamarkers are trained using biological samples and participants’ treatment responses, enabling a cost-effective qPCR test for screening individuals entering clinical trials. The predictive capabilities of Aptamarkers allow researchers to… Read More »Aptamarker Use Case: Enhancing Clinical Trials with Aptamarker Precision – Tailoring Inclusion and Exclusion Criteria
In the rapidly advancing field of molecular medicine, researchers are constantly on the lookout for innovative therapies that can target specific disease molecules with precision and efficacy. Aptamers, a class of synthetic oligonucleotides, have emerged as a promising and versatile tool in the quest for… Read More »Aptamers: A Novel Therapeutic Oligonucleotide
Aptamers are engineered molecules that can bind to specific target compounds with high affinity and selectivity, making them valuable tools in various applications. Achieving absolute specificity, or binding to a single compound exclusively, is challenging due to the structural similarities among molecules. However, aptamers can… Read More »The Specificity of Aptamers: Can They Selectively Bind to a Single Compound?
Cancer is a formidable adversary that continues to challenge the field of medicine. Despite significant advancements in cancer research and treatment, finding precise and effective methods for diagnosing and treating cancer remains a top priority. One promising avenue of research that has gained momentum in… Read More »Targeted Hope: Aptamers in the Fight Against Cancer
Aptamers are synthetic, single-stranded DNA, RNA, or peptide molecules with high specificity and affinity for a wide range of target molecules, making them valuable in diagnostics. Advantages of aptamers in diagnostics include high specificity, versatility for various target types, and stability under different environmental conditions.… Read More »Aptamers: Revolutionizing Diagnostics in the Next Generation
In the realm of modern medicine, researchers and scientists are continually exploring innovative ways to combat diseases and improve the quality of life for patients. Two emerging contenders in the therapeutic arena are antibodies and aptamers. These molecular warriors hold immense potential in diagnosing and… Read More »A Therapeutic Battle: Antibodies vs. Aptamers
One of the most remarkable aspects of the integration of aptamers with qPCR for protein detection is the unprecedented sensitivity it brings to the table. Traditional protein detection methods, such as ELISA and Western blotting, often struggle to accurately quantify proteins present in very low… Read More »Advancements in Sensitivity: qPCR’s Remarkable Detection of Proteins
We are pleased to announce that our European subsidiary company, NeoNeuro has recently succeeded with a pre-clinical trial of their blood test for brain amyloid with the collaboration of the Centro Hospitalar de Entre o Douro e Vouga, in Santa Maria da Fiera, Portugal. This… Read More »Successful Pre-clinical Trial of Aptamer-based Blood Test for Alzheimer’s Disease
Welcome to the forefront of scientific exploration, where the power of aptamers is reshaping the boundaries of medicine, diagnostics, and beyond. The aptamer frontier represents a captivating realm of discovery, where researchers and innovators are unlocking previously unimaginable applications and uncharted possibilities. In this blog,… Read More »The Aptamer Frontier: Discovering New Applications and Possibilities
Aptamers, versatile nucleic acid molecules with tremendous potential for targeted therapies and diagnostics, have gained significant attention in recent years. We are among the key players in this exciting field, known for our leadership in aptamer patenting. With employees named on 85 published patent applications… Read More »Innovating the Landscape of Aptamer Intellectual Property: A Look Inside NeoVentures and NeoNeuro
In recent years, the field of therapeutics has witnessed remarkable advancements in the development of novel treatment strategies. Among the emerging approaches, aptamers have emerged as powerful tools with immense potential in various therapeutic applications. Aptamers, short single-stranded nucleic acid or peptide molecules, can specifically… Read More »Unlocking Therapeutic Potential: Aptamers as Promising Tools in Medicine
Aptamer-based biosensors typically consist of three components: the aptamer as the recognition element, a transducer, and a signal output. The aptamer binds to the target molecule, and this binding event is then transduced into a detectable signal by the transducer. The signal output can be… Read More »What Are Aptamer-Based Biosensors & Their Applications?
In the world of molecular recognition and targeted therapies, aptamers have emerged as an alternative to antibodies. These nucleic acid molecules possess a remarkable set of characteristics that make them highly desirable in various fields, including diagnostics, therapeutics, and drug development. Aptamers exhibit exceptional specificity… Read More »Unleashing the Power of Aptamers: A Versatile Alternative to Antibodies
NeoVentures was formed as an aptamer development company in June of 2002, and founded on a very simple principle. Businesses that create real sustainable value for their clients succeed. This does not always seem to be case as we have all seen biotechnology companies that… Read More »Why has NeoVentures succeeded as an Aptamer development company?
NeoVentures is the leader for aptamer development globally because we have led and are continuing to lead with improvements to the aptamer development process. Over the past two years, we have reinvented aptamer development because this was needed. Aptamers for Diagnostics and Therapeutics Clients using… Read More »Why Should NeoVentures Develop Your Aptamers?
We recently asked which of the following applications cannot be done with aptamers? The results were overwhelmingly in favor of one choice: We can go through each option to see how aptamers are indeed able to be used in diagnostics, therapeutics, and drug discovery but… Read More »What Cannot Be Done with Aptamers?
NeoVentures is pleased to announce that a long term project with a Fortune 500 company regarding the development of an aptamer that binds to a transmembrane receptor is currently under review by the FDA. This multi-year project was contracted to NeoVentures because of our expertise… Read More »Aptamers That Bind to a Transmembrane Receptor
NeoVentures is pleased to announce the successful completion of a project with a Fortune 500 pharmaceutical company resulting in the development of aptamers as tools for high throughput biomanufacturing of drugs. The key advantage of aptamers in this type of application is the capacity to… Read More »Aptamers for Biomanufacturing of Drugs
In our “What is an aptamer” blog, we described that aptamers are synthetically made, single-stranded DNA or RNA molecules. There are inherent differences between DNA and RNA when found naturally. DNA is typically a double-stranded biomolecule composed of A, T, C, and G bases. RNA… Read More »DNA vs RNA Aptamers
Currently, at NeoVentures, we believe that there is no concrete answer to the question if aptamers are better than antibodies. We have thoughts on why aptamers would be more useful in specific cases, but there just isn’t the same amount of literature available yet on… Read More »Are Aptamers Better than Antibodies?
Aptamers are selected from large libraries of random sequences, thus aptamers themselves are not designed but the libraries that they are selected from are. The standard method of aptamer design has been for SELEX selection. This involves a synthetic library with a random region flanked… Read More »Aptamer Libraries – What is Neomers?
We thought that the World Cup was a timely icon for this blog series. This will be a blog series because there are so many reasons why we are the best aptamer company. What are they? You own the aptamers, no royalties. Innovative NEOMER aptamer… Read More »Why is NeoVentures the Best Aptamer Company for Your Needs?
What determines the binding capacity of an aptamer? Our poll results indicate that……… Nature of the target The peptide bond Nucleotide staking free energy Van der Waals forces Let’s go through the options one by one to determine the correct answer. b) The Peptide Bond. It… Read More »What Determines the Binding Capacity of an Aptamer?
Antibody Binding vs. Aptamer Binding The immune system has developed very effective screening methods for eliminating antibodies that bind even weakly to self targets such as serum albumin and IgG. Aptamer selection is done outside the body, on the bench which provides many advantages but implicit… Read More »How We Avoid Self-Recognition with Aptamers
Did you see our poll on LinkedIn? If not, check it out here! Our answer to this poll will be short and sweet: Sugars are molecules that have a generic formula of CnH2nOn. They can be described as polyhydroxy compounds containing one ether bond. Most… Read More »Can Aptamers Bind to Sugar Molecules?
I was just in Leipzig for the in-person portion of BIO-Europe 2022 that ran from October 24th to 26th. It is great to be back in person at BIO-Europe, the last event I was able to attend was in Hamburg in 2019. There were more… Read More »BIO-Europe 2022
The use of the traditional SELEX method for aptamer development has led to the identification of aptamers that bind to a wide diversity of targets. However, there has been limited success with aptamers in therapeutic and diagnostic applications. A key advantage of aptamer development over… Read More »Announcing The Future of Aptamers: Neomers
The clear winner of our poll on antibody specificity was that antibodies have evolved to ignore HAS/IgG. I struggle with this, as I think it is too simple. Really, the way that antibodies rearrange to detect foreign antigens is open; there are no barriers to… Read More »Why Do Antibodies Perform Better in Matrices than Aptamers?
The aptamer market has been growing steadily as there has been increasing awareness of the advantages of aptamers in diagnostic and therapeutic platforms. It has been reported that the global aptamer marker has been forecasted to at least double in value over the next 5… Read More »The Aptamer Market
The shape of an aptamer is very important for its binding affinity to the target. This is because the shape allows it to ‘fit’ into a target, but also orients the nucleotides involved in binding in a way that optimizes binding interactions. For aptamers to… Read More »Aptamer Design
Finding a diagnostic reagent that is right for a point-of-care application can be tricky due to the long list of obstacles that need to be overcome. The reagent needs to be shelf-stable, give reproducibly sensitive and selective results, be easy to synthesize, and most importantly,… Read More »What is An Aptamer?
Designing aptamers for specific targets needs to be done in a way that ensures you are selecting the aptamers that bind to your target while easily getting rid of those sequences that do not. Typically, this is done by immobilizing the target so that aptamers… Read More »How We Avoid Immobilizing Targets with FRELEX
In this blog series we will provide a comprehensive review of how aptamers work by comparing and contrasting them with antibodies. We consider antibodies to be equivalent to aliens and aptamers are our heroes, the cowboys, and of course we all know that the cowboys… Read More »How do Aptamers and Antibodies Work?
The relationship between structure and function is pretty obvious in a lot of engineering projects. Clearly the same is true for aptamers. The functionality of an aptamer is based entirely on it’s structure. In this series of blogs we are going to reveal how we… Read More »Aptamer Structure Prediction
I love the confidence of those responding. Basically the winning category was that aptamers work great, they just have not been tried in enough applications. In my opinion, we should have provided a fifth option in this poll, All of the above… Successful monoclonal antibody… Read More »Why Have Aptamers Not Been More Successful in Therapeutics?
This blog starts with a portrait of Claude Louis Berthollet (1748 – 1872), who was the first to demonstrate and elaborate on the concept of chemical reversibility. As an aside, it should be noted that he accompanied Napoleon to Egypt and, along with Joseph Fourier,… Read More »How Does Chemical Reversibility Impact Commercial Aptamer Diagnostics
Thanks to all who participated in our poll on why aptamers have not been commercialized in diagnostic applications. The most popular response was platforms are designed for antibodies. I will avoid commenting on the vested interest of the Illuminati because I do not want to… Read More »Why Have Aptamers Not Been Commercialized in Diagnostic Applications?
This is the first of several blogs we will share on our new Neomer process. The image above can be compared to a dilemma in traditional aptamer selection: are the aptamers that are enriching the product of the selection process (I would vote for the… Read More »How We Overcome Process Bias with Neomers
Fabergé made the egg above on commission for Dr. Emanuel Nobel, nephew of Alfred Nobel. The surprise inside is a diamond encrusted platinum and rock crystal watch. The enduring value of Fabergé eggs is due to their beauty and the painstaking craftmanship of their production. … Read More »Custom Aptamers
SELEX has been the basic method for identifying aptamers for the last thirty years. It is time for an improvement. The key constraint implicit in the SELEX method is that it is not reproducible. Every time a new starting library is selected from a synthesized… Read More »The Neomer Selection Strategy – A Game Changing Innovation From NeoVentures.
The phoenix of mythology arises from the ashes of its predecessor. This seems like a very intriguing phenomena, but strikes me as difficult to control in a commercial application. Yet, we keep getting asked whether this is necessary for aptamers to work. Do aptamers need… Read More »Why We Avoid Denaturation of Aptamers for Commercial Applications
Scriptorium was a word used in medieval times to describe a place reserved for copying manuscripts. Now, every company developing aptamer based commercial products should define their own scriptorium, even if this refers to an online space. The most important guide for all aspects of… Read More »Commercializing Aptamers: The Importance of SOPs
This blog is the last in this series, for now. This is definitely an area that we will be revisiting soon. The executive summary for this whole series, is that I think that electrochemical detection is definitely the future for aptamer based diagnosis. This is… Read More »Electrochemistry and Aptamer Summary VI
Electrical impedance spectroscopy is an approach to measuring the modulation of the surface of an electrode as a result of the binding of a target molecule with an aptamer without labeling the aptamer with a redox moiety such as methylene blue. In this approach we… Read More »Electrochemistry and Aptamers IV
In our last blog we discussed the electrical basis for square wave voltammetry. In this blog we will focus on the chemistry part of electrochemical. The powder depicted above is methylene blue (MB). This is a redox agent, meaning that this molecule is an oxidation… Read More »Square Wave Voltammetry ( SWV) and the Blue Dye.
Square waves happen in the ocean when waves in different directions cross each other. They are beautiful but dangerous for swimmers. Square wave voltammetry is similar but I think definitely less dangerous. I will use an incomprehensible introductory sentence and then deconstruct this in order… Read More »Square Wave Voltammetry (SWV) Used in Diagnostic Applications with Aptamers
COVID-19 and an increased public understanding of diagnostics. We have noticed during walks that the majority of conversations that we overhear are related to the pandemic. What is particularly striking is the use of words that pre-pandemic were part of our scientific jargon but not… Read More »The Effect of the Pandemic on Public Understanding of Healthcare
Nostradamus famously predicted many world events. I have searched for his insights on aptamers, but have come up empty. Therefore, I have realized that it falls upon us to make predictions for aptamers for 2022. There will be more than one aptamer approved by the… Read More »New Year’s Predictions
NeoVentures has upgraded their next generation sequence (NGS) from Illumina HiSeq to NovaSeq. Why is this important to you? Aptamers that will enable commercial applications in diagnostics and therapeutics have to be optimal in terms of sensitivity and specificity. The best aptamers in terms of… Read More »NeoVentures Announcement!!!
Custom design of an aptamer selection strategy that will fit your needs. This means appropriate counter selection, appropriate matrix selection, and appropriate target identification. Guidance of the selection process to ensure appropriate balance between specificity and affinity. At NeoVentures we support this by mathematically modeling… Read More »Custom Aptamers “7 steps for aptamers to be applied commercially”
In our previous post on “can aptamers replace antibodies” we mentioned some of the limitations where antibodies are unable to detect small molecules. Today we would be discussing the limitations of antibodies in Viral infections. Despite years of research, certain pathogens, such as HIV, have… Read More »Can aptamers replace antibodies ?“Neutralization of infections”
NeoVentures does not have a catalog for aptamers nor sell a pre-set aptamer development package. Your journey with us starts with our understanding of your needs for aptamer performance. We use this to develop a customized strategy for every aspect of project development from identifying… Read More »How To Buy Aptamers ?
Can aptamers replace antibodies? Almost all existing diagnostic kits are based on the use of an antibody for the target compound. A $17B industry has been built on this basis. However, antibodies have their limitations: Antibodies will not detect small molecules unless the small molecule… Read More »Aptamers Vs Antibodies
Advantages Of Aptamers Over Antibodies For diagnosis of viral infection aptamers are clearly the preferred choice over antibodies in the developing world where the need for consistent refrigeration may pose a problem. We have been able to achieve the necessary levels of sensitivity with aptamers… Read More »Aptamers Vs Antibodies
Proud to announce that we are now a verified provider on @Science Exchange, the platform for outsourced R&D. Visit our profile to request a quote right now. There are no additional contracts required if you request on Science Exchange and you can order immediately https://www.scienceexchange.com/labs/neoventures-biotechnology-inc… Read More »Verified R&D Provider
“The single biggest problem in communication is the illusion that it has taken place.” George Bernard Shaw In this blog, I am staying on the theme of commercialization of aptamers, leading up to our forthcoming webinar on aptamer commercialization on October 20th. The focus of… Read More »Commercializing Aptamers Part 6
“A person is a person no matter how small” Dr. Seuss in Horton’s Hears a Who I am not sure how well distributed Dr. Seuss books are outside of North America. They were a staple of my childhood, and I made sure that they were… Read More »The Advantage of shorter Aptamers
This icon was on the cover of Zen and the Art of Motorcycle Maintenance which we introduced in the previous blog. “And it occurred to me there is no manual that deals with the real business of motorcycle maintenance, the most important aspect of all.… Read More »Commercializing Aptamers Part 5
The picture above is of Robert Pirsig, author of Zen and the Art of Motorcycle Maintenance. This book had a profound impact on me. He articulates the thought that a high level of engagement is necessary for excellence, and that this is also the key… Read More »Aptamer commercialization IV
The painting above is an early Van Gogh from Paris. You can see the basis for the talent that was to follow but it is also easy to see why this painting did not sell. Commercializing a new product is implicitly a conflict between adding… Read More »Commercializing Aptamers III
One of my parents favourite movies was “Kind Hearts and Coronets” which describes the personal history of a nobleman who was I think 11th in line to a title. All of the characters shown in the poster were actually played by Alec Guinness. He successfully… Read More »Aptamer Commercialization II
Skoll is the name of the wolf, Who follows the shining priest, Into the desolate forest, And the other is Hati, Hróðvitnir’s son, Who chases the bright bride of the sky Snorri Sturluson’s Grímnismál I chose Norse mythology as a description of the cause of solar… Read More »Aptamer Chemistry Series IV: Fluorescence and Aptamers
Don Quixote spent four days coming up with a name for his horse, Rocinante, as the name had to befit a horse of such a great knight. The name Rocinante represents clever word play in Spanish, as “ante” means before, and “rocin” means a nag… Read More »Aptamer Chemistry Series III
At NeoVentures we are global leaders in the development and application of chemistries that enable aptamer performance in diagnostic devices. Usually I start my blogs with a cultural analogy, sorry to disappoint with the adapter image this time. The reason for the analogy is to… Read More »Aptamer Chemistry Series II : The Adapter
Bernard Trevisan ,an unfortunately fictional character, is attributed with spending his life in the scientific pursuit of the Philospher’s Stone, a substance that could transform a base metal into gold. Although Bernard was not ultimately successful, he represents all of those alchemists who built the… Read More »Aptamer Chemistry : The Philosopher’s Stone
Robert Frost’s poem, “Two roads diverged in a yellow wood, … I took the one less traveled by,. And that has made all the difference …” may be useful advice for life, but not when preparing a path for new products that will be subject to regulatory approval. Developing new… Read More »Modified Nucleotides: Follow the Vaccines
“The universe (which others call the Library) is composed of an indefinite, perhaps infinite number of hexagonal galleries.” ― Jorge Luis Borges, quote from The Library of Babel (https://en.wikipedia.org/wiki/The_Library_of_Babel) A library of aptamers is like a library of books. They both contain strings of information… Read More »FRELEX III: Aptamarkers
Think about listening to great jazz, late at night in a quiet club. The saxophone riffs off a melody laid down by the trumpet and vice-versa back and forth. The complexity of the interacting sounds takes us away from the expected melody in eddies drifting… Read More »FRELEX : Enabling diagnosis of complexes.
In the M.C. Escher painting, “Reptiles” it is clear how much more information is present in the three-dimensional representation of the lizards versus their two-dimensional counterparts. The three-dimensional lizards are alive, they are bending over and interacting with surfaces. I will argue that the situation… Read More »FRELEX: “The concept”
When we look at the night’s sky and see the moon, we could describe their relationship as a fixed binding event. In fact, this is a dynamic system where the earth, the moon and the sun play a role. The same as the earth and… Read More »Signal versus Noise IV: Binding affinity
Signal strength In 1880, Pyotr Ilyich Tchaikovsky was commissioned to create an overture to commemorate the defeat of Napoleon’s grand armée outside of Moscow in 1812. His use of 16 real cannons as part of the percussion section has definitely made this piece stand out… Read More »Signal Versus Noise III
Mariners knew that there were dangers in uncharted waters and those that wandered there may not come back. It is safe to work with aptamers in controlled buffers and many papers have been published detailing how well they work close to the shore where maps… Read More »Signal Versus Noise II
Signal versus noise is not only the core basis of the development of diagnostic devices but the core basis of all scientific questions. This may be the core question of our individual existence as a brief scream against the silence of the universe, but that… Read More »Signal versus noise
At NeoVentures we are the global leaders in the identification of aptamers against viruses. We have developed aptamers against HIV, HCV, HSV, rhinovirus, and SARS-CoV-2 for a broad range of applications from neutralization of infection to diagnosis. Why aptamers for these applications? For neutralization of… Read More »Aptamers for virus infection , prevention and diagnosis
Why consider aptamers for therapeutic applications? There has only been one aptamer based therapeutic ever approved, Macugen (https://en.wikipedia.org/wiki/Pegaptanib) and the commercial sales for this treatment were not blockbuster… The biggest issue facing any therapeutic development effort is definitely the risk of failure, especially the risk… Read More »Why Consider Aptamers for therapeutic Applications ?
We have succeeded in developing high affinity and high specificity aptamers for both the spike protein (S1) and the nucleoprotein from SARS-CoV-2 (COVID-19). These aptamers have been characterized and are available for purchase. We are working with several partners globally to apply these aptamers in… Read More »NeoVentures Develops Aptamers for COVID-19
NeoVentures has successfully developed aptamers for both the spike protein and the nucleoprotein of SARS-CoV-2 (COVID-19). Spike protein aptamers were developed against a recombinant S1 protein from the Wuhan strain expressed in HEK293 cells in order to maintain appropriate glycosylation, counter selection was performed against… Read More »Neo Ventures Announcement
Why are there not more aptamer based therapeutics? This blog by Drew Smith in 2019 nails a lot of the reasons, and in particular the issues related to the rapid clearance of aptamers from the body. https://drewsmithblog.com/2019/05/aptamers-still-looking-for-euphoria-in-the-wrong-places/. He effectively points out that the aptamer that… Read More »Aptamers in therapeutics ? (Why not)
In a previous blog I stressed the need to further improve aptamer performance after SELEX identification in order to develop aptamers that are effective enough to be commercialized. I promised that I would describe how we do this at NeoVentures in more detail in a… Read More »Optimized Aptamers II
In the ever-evolving field of diagnostics, precision and predictability are key to developing reliable products. However, the traditional reliance on antibodies poses significant challenges due to the inherent uncertainties in measuring their binding affinity and quantity. This creates a complex, two-variable problem that complicates product… Read More »The Aptamer Advantage: Breaking Free from Antibody Uncertainty
For aptamers to be able to compete with antibodies in health care applications they need to perform as well as antibodies. At NeoVentures we have considered how antibodies evolve in response to an antigen and we have applied a similar approach to the optimization of… Read More »Optimized Aptamers
In the rapidly evolving field of biotechnology, researchers constantly develop new tools and technologies to address pressing matters. One such technology that has been gaining significant attention is aptamers. These versatile, single-stranded DNA or RNA molecules have the unique ability to bind to specific targets.… Read More »Advantages of Aptamers – Why You Should Know Aptamers!
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