By Gregory Penner (NeoVentures Biotechnology) and Natasha Paul, PhD (TriLink Biotechnologies, LLC)
One of the key assumptions of aptamer selection is that the composition of the starting random library is in fact random. Any bias from randomness can cause misrepresentation of sequence space, which can in turn limit the search for aptamers that bind the desired target with high specificity. NeoVentures and TriLink came together to confirm the randomness of the TriLink library manufacturing process.