This blog starts with a portrait of Claude Louis Berthollet (1748 – 1872), who was the first to demonstrate and elaborate on the concept of chemical reversibility. As an aside, it should be noted that he accompanied Napoleon to Egypt and, along with Joseph Fourier,… Leer más »How Does Chemical Reversibility Impact Commercial Aptamer Diagnostics
Thanks to all who participated in our poll on why aptamers have not been commercialized in diagnostic applications. The most popular response was platforms are designed for antibodies. I will avoid commenting on the vested interest of the Illuminati because I do not want to… Leer más »Why Have Aptamers Not Been Commercialized in Diagnostic Applications?
This is the first of several blogs we will share on our new Neomer process. The image above can be compared to a dilemma in traditional aptamer selection: are the aptamers that are enriching the product of the selection process (I would vote for the… Leer más »How We Overcome Process Bias with Neomers
Fabergé made the egg above on commission for Dr. Emanuel Nobel, nephew of Alfred Nobel. The surprise inside is a diamond encrusted platinum and rock crystal watch. The enduring value of Fabergé eggs is due to their beauty and the painstaking craftmanship of their production. … Leer más »Aptámeros Personalizados
SELEX has been the basic method for identifying aptamers for the last thirty years. It is time for an improvement. The key constraint implicit in the SELEX method is that it is not reproducible. Every time a new starting library is selected from a synthesized… Leer más »The Neomer Selection Strategy – A Game Changing Innovation From NeoVentures.
The phoenix of mythology arises from the ashes of its predecessor. This seems like a very intriguing phenomena, but strikes me as difficult to control in a commercial application. Yet, we keep getting asked whether this is necessary for aptamers to work. Do aptamers need… Leer más »Why We Avoid Denaturation of Aptamers for Commercial Applications
Scriptorium was a word used in medieval times to describe a place reserved for copying manuscripts. Now, every company developing aptamer based commercial products should define their own scriptorium, even if this refers to an online space. The most important guide for all aspects of… Leer más »Commercializing Aptamers: The Importance of SOPs
This blog is the last in this series, for now. This is definitely an area that we will be revisiting soon. The executive summary for this whole series, is that I think that electrochemical detection is definitely the future for aptamer based diagnosis. This is… Leer más »Electrochemistry and Aptamer Summary VI
Electrical impedance spectroscopy is an approach to measuring the modulation of the surface of an electrode as a result of the binding of a target molecule with an aptamer without labeling the aptamer with a redox moiety such as methylene blue. In this approach we… Leer más »Electrochemistry and Aptamers IV
In our last blog we discussed the electrical basis for square wave voltammetry. In this blog we will focus on the chemistry part of electrochemical. The powder depicted above is methylene blue (MB). This is a redox agent, meaning that this molecule is an oxidation… Leer más »Square Wave Voltammetry ( SWV) and the Blue Dye.
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