“The definition of insanity is doing the same thing over and over and expecting different results.” Albert Einstein- PART 2 If you’ve been following along with the previous blog post, we explored what had been the constraints for the commercialization of aptamer-based diagnostics. Today, we’re picking… Leer más »The Future of Aptamers in Diagnostics -Part II
“The definition of insanity is doing the same thing over and over and expecting different results.” – Albert Einstein The Future of Aptamers in Diagnostics – Part 1 Aptamers have not fulfilled the promise of significantly replacing antibodies as the basis for diagnosis, with very little… Leer más »The Future of Aptamers in Diagnostics – Part 1
Reinventing Aptamer Science: The Neomer Platform In 2022, NeoVentures Biotechnology revolutionized aptamer science by introducing reproducibility, paving the way for the next generation of aptamers. Using our neomer platform, we reduced the number of random nucleotides while preserving optimal structural diversity. This innovation addressed the… Leer más »The Next Generation of Aptamers
Ludwig Mies van der Rohe, famously said of architecture that “Less is more”. This principle is based on the idea that removing superfluous elements enhances the clarity of the concept. It emphasizes functionality, clean aesthetics and simplicity. The German pavilion that he designed for the… Leer más »Aptamer architecture: Less is more in truncations
The Enzyme-Linked Immunosorbent Assay (ELISA) was invented by Swedish scientists Eva Engvall and Peter Perlmann in 1971. This groundbreaking diagnostic method revolutionized medicine by using antibodies to detect the presence of specific hormones or viruses, providing results much faster than traditional methods. The Enzyme-Linked Immunosorbent… Leer más »The Enzyme-Linked Oligonucleotide Assay. The aptamer ELISA.
Background: By translating information on protein abundance to information on DNA abundance High-Plex proteomics brings deeper analysis than transcriptomics on a protein level. Pioneers like Olink and Somalogic have been leaders in building a future based on protein abundance. There are, however, weaknesses in the… Leer más »The Aptamarker Platform
Keys to solving problems with aptamers: Obtain good specific aptamers We think that the only way to reliably obtain aptamers that will be specific enough for commercial applications is to use our reinvented Neomer library approach. Aptamer quality should be based on scientifically stringent binding… Leer más »The NeoVentures’ Business Strategy Part 2
CRO: contract research organization. A company that provides support to the pharmaceutical, biotechnology, and medical device industries in the form of research services outsourced on a contract basis. At NeoVentures, we do not consider ourselves as a (CRO). We approach what we do more as co-entrepreneurs with you. Clients come to… Leer más »The NeoVentures’ Business Strategy Part 1
In year three of the French revolution, a law was enacted to realize the rallying cry, “un roi, une loi, un poids, et une mesure” (One king, one law, one weight, and one measure) and this became the introduction of the metric system. The one… Leer más »The Importance Of What Is Difficult To Measure: How NeoVentures’ Aptamarker Platform Is Setting New Standards in Protein Measurement
Una historia incluida en Las Mil y Una Noches es la historia de Aladino. Un niño pobre que un día logra engañar al malvado hechicero y obtener la lámpara mágica. Dentro de la lámpara vive el genio, quien le concederá todos sus deseos. Ahora,... Leer más »Por qué los anticuerpos desearían ser ADN
En el dinámico ámbito de la biología molecular, la búsqueda de mejorar herramientas diagnósticas y enfoques terapéuticos es un viaje en constante evolución. Un avance significativo en esta búsqueda es el desarrollo de la biblioteca Neomer, una plataforma innovadora que permite la utilización de secuencias idénticas en diversas... Leer más »Desatando el Potencial de la Biblioteca Neomer: Un Enfoque Revolucionario para la Caracterización y Mejora de Aptámeros.
Construcción del Espacio Molecular: La plataforma de Aptamarcadores de NeoVentures Biotechnology aprovecha el análisis de Aptamarcadores para construir un espacio molecular, donde los individuos se agrupan según perfiles biomoleculares únicos. Este espacio captura la diversidad en las respuestas a enfermedades y permite la exploración matizada de diferentes procesos fisiopatológicos que llevan a la misma... Leer más »Caso de uso de Aptamarcadores: Navegando el Paisaje Molecular: Aptamarcadores como la Brújula para la Estratificación de Pacientes.
Descubrimiento Revolucionario de Biomarcadores: Aptamarcador permite el cribado agnóstico de biomarcadores, transformando la comprensión de las enfermedades. Facilita la estratificación de pacientes en ensayos clínicos para una medicina de precisión y seguridad mejorada. Desarrollo de Medicamentos Predictivos y Precisos: Predice efectos secundarios y traduce hallazgos en modelos animales para un desarrollo de medicamentos más seguro. Mapea los sitios de unión de fármacos... Leer más »Liberando el Poder de los Aptamarcadores: Una Nueva Frontera en el Manejo de Enfermedades.
Cambio de Paradigma de Aptamarcadores: La plataforma de Aptamarcadores de NeoVentures Biotechnology desafía el enfoque tradicional de descubrimiento de biomarcadores al eliminar la necesidad de comprender primero la causa de una enfermedad. Revolucionando la Atención Médica: Aptamarcador permite la identificación de biomarcadores de enfermedades sin las limitaciones de desentrañar la causa de la enfermedad, lo que conduce a una... Leer más »Revolucionando la Detección de Enfermedades: La Plataforma de Aptamarcadores de NeoVentures Biotechnology
El método de selección de aptámeros Neomer de NeoVentures reemplaza el proceso tradicional SELEX, ofreciendo un espacio cerrado y reproducible para el desarrollo de aptámeros, asegurando consistencia en la detección de niveles de medicamentos. La inclusión de un paso de tolerancia inmune in-silico mejora la especificidad y selectividad de los aptámeros Neomer, haciéndolos más precisos en la detección... Leer más »Revolucionando la Detección de Niveles de Medicamentos: Los Aptámeros Neomer de NeoVentures Toman la Delantera
Ventaja de Tolerancia Inmune de los Aptamarcadores: Los Aptamarcadores superan los problemas de tolerancia inmune en el desarrollo tradicional de anticuerpos. Aptamarcadores vs. Anticuerpos: Una Ventaja Cuantitativa: Un espectro de reconocimiento más amplio alinea el panorama de biomarcadores en modelos animales más estrechamente con el contexto humano. Entrenamiento de Aptamarcadores en Ensayos en Animales: Los Aptamarcadores pueden ser entrenados... Leer más »Caso de Uso de Aptamarcadores: Rompiendo Barreras - Los Aptamarcadores Allanan el Camino para una Traducción sin Problemas desde los Ensayos en Animales hasta los Ensayos en Humanos.
La plataforma de Aptamarcadores de NeoVentures Biotechnology revoluciona los ensayos clínicos al introducir criterios de inclusión y exclusión personalizados y predictivos. Los Aptamarcadores son entrenados utilizando muestras biológicas y respuestas al tratamiento de los participantes, lo que permite una prueba de qPCR rentable para la selección de individuos que ingresan a los ensayos clínicos. Las capacidades predictivas de los Aptamarcadores permiten a los investigadores... Leer más »Caso de Uso de Aptamarcadores: Mejorando los Ensayos Clínicos con Precisión de Aptamarcadores - Adaptando los Criterios de Inclusión y Exclusión
En el campo en constante avance de la medicina molecular, los investigadores están constantemente buscando terapias innovadoras que puedan dirigirse con precisión y eficacia a moléculas específicas de enfermedades. Los aptámeros, una clase de oligonucleótidos sintéticos, han surgido como una herramienta prometedora y versátil en la búsqueda de... Leer más »Aptámeros: Un Oligonucleótido Terapéutico Innovador
Los aptámeros son moléculas diseñadas que pueden unirse a compuestos específicos con alta afinidad y selectividad, lo que los convierte en herramientas valiosas en diversas aplicaciones. Lograr una especificidad absoluta, es decir, unirse exclusivamente a un solo compuesto, es un desafío debido a las similitudes estructurales entre las moléculas. Sin embargo, los aptámeros pueden... Leer más »La Especificidad de los Aptámeros: ¿Pueden unirse selectivamente a un único compuesto?
Cancer is a formidable adversary that continues to challenge the field of medicine. Despite significant advancements in cancer research and treatment, finding precise and effective methods for diagnosing and treating cancer remains a top priority. One promising avenue of research that has gained momentum in… Leer más »Targeted Hope: Aptamers in the Fight Against Cancer
Aptamers are synthetic, single-stranded DNA, RNA, or peptide molecules with high specificity and affinity for a wide range of target molecules, making them valuable in diagnostics. Advantages of aptamers in diagnostics include high specificity, versatility for various target types, and stability under different environmental conditions.… Leer más »Aptamers: Revolutionizing Diagnostics in the Next Generation
In the realm of modern medicine, researchers and scientists are continually exploring innovative ways to combat diseases and improve the quality of life for patients. Two emerging contenders in the therapeutic arena are antibodies and aptamers. These molecular warriors hold immense potential in diagnosing and… Leer más »A Therapeutic Battle: Antibodies vs. Aptamers
One of the most remarkable aspects of the integration of aptamers with qPCR for protein detection is the unprecedented sensitivity it brings to the table. Traditional protein detection methods, such as ELISA and Western blotting, often struggle to accurately quantify proteins present in very low… Leer más »Advancements in Sensitivity: qPCR’s Remarkable Detection of Proteins
We are pleased to announce that our European subsidiary company, NeoNeuro has recently succeeded with a pre-clinical trial of their blood test for brain amyloid with the collaboration of the Centro Hospitalar de Entre o Douro e Vouga, in Santa Maria da Fiera, Portugal. This… Leer más »Successful Pre-clinical Trial of Aptamer-based Blood Test for Alzheimer’s Disease
Welcome to the forefront of scientific exploration, where the power of aptamers is reshaping the boundaries of medicine, diagnostics, and beyond. The aptamer frontier represents a captivating realm of discovery, where researchers and innovators are unlocking previously unimaginable applications and uncharted possibilities. In this blog,… Leer más »The Aptamer Frontier: Discovering New Applications and Possibilities
Aptamers, versatile nucleic acid molecules with tremendous potential for targeted therapies and diagnostics, have gained significant attention in recent years. We are among the key players in this exciting field, known for our leadership in aptamer patenting. With employees named on 85 published patent applications… Leer más »Innovating the Landscape of Aptamer Intellectual Property: A Look Inside NeoVentures and NeoNeuro
In recent years, the field of therapeutics has witnessed remarkable advancements in the development of novel treatment strategies. Among the emerging approaches, aptamers have emerged as powerful tools with immense potential in various therapeutic applications. Aptamers, short single-stranded nucleic acid or peptide molecules, can specifically… Leer más »Unlocking Therapeutic Potential: Aptamers as Promising Tools in Medicine
Aptamer-based biosensors typically consist of three components: the aptamer as the recognition element, a transducer, and a signal output. The aptamer binds to the target molecule, and this binding event is then transduced into a detectable signal by the transducer. The signal output can be… Leer más »What Are Aptamer-Based Biosensors & Their Applications?
In the world of molecular recognition and targeted therapies, aptamers have emerged as an alternative to antibodies. These nucleic acid molecules possess a remarkable set of characteristics that make them highly desirable in various fields, including diagnostics, therapeutics, and drug development. Aptamers exhibit exceptional specificity… Leer más »Unleashing the Power of Aptamers: A Versatile Alternative to Antibodies
NeoVentures was formed as an aptamer development company in June of 2002, and founded on a very simple principle. Businesses that create real sustainable value for their clients succeed. This does not always seem to be case as we have all seen biotechnology companies that… Leer más »Why has NeoVentures succeeded as an Aptamer development company?
NeoVentures is the leader for aptamer development globally because we have led and are continuing to lead with improvements to the aptamer development process. Over the past two years, we have reinvented aptamer development because this was needed. Aptamers for Diagnostics and Therapeutics Clients using… Leer más »Why Should NeoVentures Develop Your Aptamers?
We recently asked which of the following applications cannot be done with aptamers? The results were overwhelmingly in favor of one choice: We can go through each option to see how aptamers are indeed able to be used in diagnostics, therapeutics, and drug discovery but… Leer más »What Cannot Be Done with Aptamers?
NeoVentures is pleased to announce that a long term project with a Fortune 500 company regarding the development of an aptamer that binds to a transmembrane receptor is currently under review by the FDA. This multi-year project was contracted to NeoVentures because of our expertise… Leer más »Aptamers That Bind to a Transmembrane Receptor
NeoVentures is pleased to announce the successful completion of a project with a Fortune 500 pharmaceutical company resulting in the development of aptamers as tools for high throughput biomanufacturing of drugs. The key advantage of aptamers in this type of application is the capacity to… Leer más »Aptamers for Biomanufacturing of Drugs
In our “What is an aptamer” blog, we described that aptamers are synthetically made, single-stranded DNA or RNA molecules. There are inherent differences between DNA and RNA when found naturally. DNA is typically a double-stranded biomolecule composed of A, T, C, and G bases. RNA… Leer más »DNA vs RNA Aptamers
Currently, at NeoVentures, we believe that there is no concrete answer to the question if aptamers are better than antibodies. We have thoughts on why aptamers would be more useful in specific cases, but there just isn’t the same amount of literature available yet on… Leer más »Are Aptamers Better than Antibodies?
Aptamers are selected from large libraries of random sequences, thus aptamers themselves are not designed but the libraries that they are selected from are. The standard method of aptamer design has been for SELEX selection. This involves a synthetic library with a random region flanked… Leer más »Aptamer Libraries – What is Neomers?
We thought that the World Cup was a timely icon for this blog series. This will be a blog series because there are so many reasons why we are the best aptamer company. What are they? You own the aptamers, no royalties. Innovative NEOMER aptamer… Leer más »Why is NeoVentures the Best Aptamer Company for Your Needs?
What determines the binding capacity of an aptamer? Our poll results indicate that……… Nature of the target The peptide bond Nucleotide staking free energy Van der Waals forces Let’s go through the options one by one to determine the correct answer. b) The Peptide Bond. It… Leer más »What Determines the Binding Capacity of an Aptamer?
Antibody Binding vs. Aptamer Binding The immune system has developed very effective screening methods for eliminating antibodies that bind even weakly to self targets such as serum albumin and IgG. Aptamer selection is done outside the body, on the bench which provides many advantages but implicit… Leer más »How We Avoid Self-Recognition with Aptamers
Did you see our poll on LinkedIn? If not, check it out here! Our answer to this poll will be short and sweet: Sugars are molecules that have a generic formula of CnH2nOn. They can be described as polyhydroxy compounds containing one ether bond. Most… Leer más »Can Aptamers Bind to Sugar Molecules?
I was just in Leipzig for the in-person portion of BIO-Europe 2022 that ran from October 24th to 26th. It is great to be back in person at BIO-Europe, the last event I was able to attend was in Hamburg in 2019. There were more… Leer más »BIO-Europe 2022
The use of the traditional SELEX method for aptamer development has led to the identification of aptamers that bind to a wide diversity of targets. However, there has been limited success with aptamers in therapeutic and diagnostic applications. A key advantage of aptamer development over… Leer más »Announcing The Future of Aptamers: Neomers
The clear winner of our poll on antibody specificity was that antibodies have evolved to ignore HAS/IgG. I struggle with this, as I think it is too simple. Really, the way that antibodies rearrange to detect foreign antigens is open; there are no barriers to… Leer más »Why Do Antibodies Perform Better in Matrices than Aptamers?
The aptamer market has been growing steadily as there has been increasing awareness of the advantages of aptamers in diagnostic and therapeutic platforms. It has been reported that the global aptamer marker has been forecasted to at least double in value over the next 5… Leer más »The Aptamer Market
The shape of an aptamer is very important for its binding affinity to the target. This is because the shape allows it to ‘fit’ into a target, but also orients the nucleotides involved in binding in a way that optimizes binding interactions. For aptamers to… Leer más »Aptamer Design
Finding a diagnostic reagent that is right for a point-of-care application can be tricky due to the long list of obstacles that need to be overcome. The reagent needs to be shelf-stable, give reproducibly sensitive and selective results, be easy to synthesize, and most importantly,… Leer más »What is An Aptamer?
Designing aptamers for specific targets needs to be done in a way that ensures you are selecting the aptamers that bind to your target while easily getting rid of those sequences that do not. Typically, this is done by immobilizing the target so that aptamers… Leer más »How We Avoid Immobilizing Targets with FRELEX
In this blog series we will provide a comprehensive review of how aptamers work by comparing and contrasting them with antibodies. We consider antibodies to be equivalent to aliens and aptamers are our heroes, the cowboys, and of course we all know that the cowboys… Leer más »How do Aptamers and Antibodies Work?
The relationship between structure and function is pretty obvious in a lot of engineering projects. Clearly the same is true for aptamers. The functionality of an aptamer is based entirely on it’s structure. In this series of blogs we are going to reveal how we… Leer más »Aptamer Structure Prediction
I love the confidence of those responding. Basically the winning category was that aptamers work great, they just have not been tried in enough applications. In my opinion, we should have provided a fifth option in this poll, All of the above… Successful monoclonal antibody… Leer más »Why Have Aptamers Not Been More Successful in Therapeutics?
This blog starts with a portrait of Claude Louis Berthollet (1748 – 1872), who was the first to demonstrate and elaborate on the concept of chemical reversibility. As an aside, it should be noted that he accompanied Napoleon to Egypt and, along with Joseph Fourier,… Leer más »How Does Chemical Reversibility Impact Commercial Aptamer Diagnostics
Thanks to all who participated in our poll on why aptamers have not been commercialized in diagnostic applications. The most popular response was platforms are designed for antibodies. I will avoid commenting on the vested interest of the Illuminati because I do not want to… Leer más »Why Have Aptamers Not Been Commercialized in Diagnostic Applications?
This is the first of several blogs we will share on our new Neomer process. The image above can be compared to a dilemma in traditional aptamer selection: are the aptamers that are enriching the product of the selection process (I would vote for the… Leer más »How We Overcome Process Bias with Neomers
Fabergé made the egg above on commission for Dr. Emanuel Nobel, nephew of Alfred Nobel. The surprise inside is a diamond encrusted platinum and rock crystal watch. The enduring value of Fabergé eggs is due to their beauty and the painstaking craftmanship of their production. … Leer más »Aptámeros Personalizados
SELEX has been the basic method for identifying aptamers for the last thirty years. It is time for an improvement. The key constraint implicit in the SELEX method is that it is not reproducible. Every time a new starting library is selected from a synthesized… Leer más »The Neomer Selection Strategy – A Game Changing Innovation From NeoVentures.
The phoenix of mythology arises from the ashes of its predecessor. This seems like a very intriguing phenomena, but strikes me as difficult to control in a commercial application. Yet, we keep getting asked whether this is necessary for aptamers to work. Do aptamers need… Leer más »Why We Avoid Denaturation of Aptamers for Commercial Applications
Scriptorium was a word used in medieval times to describe a place reserved for copying manuscripts. Now, every company developing aptamer based commercial products should define their own scriptorium, even if this refers to an online space. The most important guide for all aspects of… Leer más »Commercializing Aptamers: The Importance of SOPs
This blog is the last in this series, for now. This is definitely an area that we will be revisiting soon. The executive summary for this whole series, is that I think that electrochemical detection is definitely the future for aptamer based diagnosis. This is… Leer más »Electrochemistry and Aptamer Summary VI
Electrical impedance spectroscopy is an approach to measuring the modulation of the surface of an electrode as a result of the binding of a target molecule with an aptamer without labeling the aptamer with a redox moiety such as methylene blue. In this approach we… Leer más »Electrochemistry and Aptamers IV
In our last blog we discussed the electrical basis for square wave voltammetry. In this blog we will focus on the chemistry part of electrochemical. The powder depicted above is methylene blue (MB). This is a redox agent, meaning that this molecule is an oxidation… Leer más »Square Wave Voltammetry ( SWV) and the Blue Dye.
Square waves happen in the ocean when waves in different directions cross each other. They are beautiful but dangerous for swimmers. Square wave voltammetry is similar but I think definitely less dangerous. I will use an incomprehensible introductory sentence and then deconstruct this in order… Leer más »Square Wave Voltammetry (SWV) Used in Diagnostic Applications with Aptamers
COVID-19 and an increased public understanding of diagnostics. We have noticed during walks that the majority of conversations that we overhear are related to the pandemic. What is particularly striking is the use of words that pre-pandemic were part of our scientific jargon but not… Leer más »The Effect of the Pandemic on Public Understanding of Healthcare
Nostradamus famously predicted many world events. I have searched for his insights on aptamers, but have come up empty. Therefore, I have realized that it falls upon us to make predictions for aptamers for 2022. There will be more than one aptamer approved by the… Leer más »New Year’s Predictions
NeoVentures has upgraded their next generation sequence (NGS) from Illumina HiSeq to NovaSeq. Why is this important to you? Aptamers that will enable commercial applications in diagnostics and therapeutics have to be optimal in terms of sensitivity and specificity. The best aptamers in terms of… Leer más »NeoVentures Announcement!!!
Custom design of an aptamer selection strategy that will fit your needs. This means appropriate counter selection, appropriate matrix selection, and appropriate target identification. Guidance of the selection process to ensure appropriate balance between specificity and affinity. At NeoVentures we support this by mathematically modeling… Leer más »Custom Aptamers “7 steps for aptamers to be applied commercially”
In our previous post on “can aptamers replace antibodies” we mentioned some of the limitations where antibodies are unable to detect small molecules. Today we would be discussing the limitations of antibodies in Viral infections. Despite years of research, certain pathogens, such as HIV, have… Leer más »Can aptamers replace antibodies ?“Neutralization of infections”
NeoVentures does not have a catalog for aptamers nor sell a pre-set aptamer development package. Your journey with us starts with our understanding of your needs for aptamer performance. We use this to develop a customized strategy for every aspect of project development from identifying… Leer más »How To Buy Aptamers ?
Can aptamers replace antibodies? Almost all existing diagnostic kits are based on the use of an antibody for the target compound. A $17B industry has been built on this basis. However, antibodies have their limitations: Antibodies will not detect small molecules unless the small molecule… Leer más »Aptamers Vs Antibodies
Advantages Of Aptamers Over Antibodies For diagnosis of viral infection aptamers are clearly the preferred choice over antibodies in the developing world where the need for consistent refrigeration may pose a problem. We have been able to achieve the necessary levels of sensitivity with aptamers… Leer más »Aptamers Vs Antibodies
Proud to announce that we are now a verified provider on @Science Exchange, the platform for outsourced R&D. Visit our profile to request a quote right now. There are no additional contracts required if you request on Science Exchange and you can order immediately https://www.scienceexchange.com/labs/neoventures-biotechnology-inc… Leer más »Verified R&D Provider
“The single biggest problem in communication is the illusion that it has taken place.” George Bernard Shaw In this blog, I am staying on the theme of commercialization of aptamers, leading up to our forthcoming webinar on aptamer commercialization on October 20th. The focus of… Leer más »Commercializing Aptamers Part 6
“A person is a person no matter how small” Dr. Seuss in Horton’s Hears a Who I am not sure how well distributed Dr. Seuss books are outside of North America. They were a staple of my childhood, and I made sure that they were… Leer más »The Advantage of shorter Aptamers
This icon was on the cover of Zen and the Art of Motorcycle Maintenance which we introduced in the previous blog. “And it occurred to me there is no manual that deals with the real business of motorcycle maintenance, the most important aspect of all.… Leer más »Commercializing Aptamers Part 5
The picture above is of Robert Pirsig, author of Zen and the Art of Motorcycle Maintenance. This book had a profound impact on me. He articulates the thought that a high level of engagement is necessary for excellence, and that this is also the key… Leer más »Aptamer commercialization IV
The painting above is an early Van Gogh from Paris. You can see the basis for the talent that was to follow but it is also easy to see why this painting did not sell. Commercializing a new product is implicitly a conflict between adding… Leer más »Commercializing Aptamers III
One of my parents favourite movies was “Kind Hearts and Coronets” which describes the personal history of a nobleman who was I think 11th in line to a title. All of the characters shown in the poster were actually played by Alec Guinness. He successfully… Leer más »Aptamer Commercialization II
Skoll is the name of the wolf, Who follows the shining priest, Into the desolate forest, And the other is Hati, Hróðvitnir’s son, Who chases the bright bride of the sky Snorri Sturluson’s Grímnismál I chose Norse mythology as a description of the cause of solar… Leer más »Aptamer Chemistry Series IV: Fluorescence and Aptamers
Don Quixote spent four days coming up with a name for his horse, Rocinante, as the name had to befit a horse of such a great knight. The name Rocinante represents clever word play in Spanish, as “ante” means before, and “rocin” means a nag… Leer más »Aptamer Chemistry Series III
At NeoVentures we are global leaders in the development and application of chemistries that enable aptamer performance in diagnostic devices. Usually I start my blogs with a cultural analogy, sorry to disappoint with the adapter image this time. The reason for the analogy is to… Leer más »Aptamer Chemistry Series II : The Adapter
Bernard Trevisan ,an unfortunately fictional character, is attributed with spending his life in the scientific pursuit of the Philospher’s Stone, a substance that could transform a base metal into gold. Although Bernard was not ultimately successful, he represents all of those alchemists who built the… Leer más »Aptamer Chemistry : The Philosopher’s Stone
Robert Frost’s poem, “Two roads diverged in a yellow wood, … I took the one less traveled by,. And that has made all the difference …” may be useful advice for life, but not when preparing a path for new products that will be subject to regulatory approval. Developing new… Leer más »Modified Nucleotides: Follow the Vaccines
“The universe (which others call the Library) is composed of an indefinite, perhaps infinite number of hexagonal galleries.” ― Jorge Luis Borges, quote from The Library of Babel (https://en.wikipedia.org/wiki/The_Library_of_Babel) A library of aptamers is like a library of books. They both contain strings of information… Leer más »FRELEX III: Aptamarkers
Think about listening to great jazz, late at night in a quiet club. The saxophone riffs off a melody laid down by the trumpet and vice-versa back and forth. The complexity of the interacting sounds takes us away from the expected melody in eddies drifting… Leer más »FRELEX : Enabling diagnosis of complexes.
In the M.C. Escher painting, “Reptiles” it is clear how much more information is present in the three-dimensional representation of the lizards versus their two-dimensional counterparts. The three-dimensional lizards are alive, they are bending over and interacting with surfaces. I will argue that the situation… Leer más »FRELEX: “The concept”
When we look at the night’s sky and see the moon, we could describe their relationship as a fixed binding event. In fact, this is a dynamic system where the earth, the moon and the sun play a role. The same as the earth and… Leer más »Signal versus Noise IV: Binding affinity
Signal strength In 1880, Pyotr Ilyich Tchaikovsky was commissioned to create an overture to commemorate the defeat of Napoleon’s grand armée outside of Moscow in 1812. His use of 16 real cannons as part of the percussion section has definitely made this piece stand out… Leer más »Signal Versus Noise III
Mariners knew that there were dangers in uncharted waters and those that wandered there may not come back. It is safe to work with aptamers in controlled buffers and many papers have been published detailing how well they work close to the shore where maps… Leer más »Signal Versus Noise II
Signal versus noise is not only the core basis of the development of diagnostic devices but the core basis of all scientific questions. This may be the core question of our individual existence as a brief scream against the silence of the universe, but that… Leer más »Signal versus noise
At NeoVentures we are the global leaders in the identification of aptamers against viruses. We have developed aptamers against HIV, HCV, HSV, rhinovirus, and SARS-CoV-2 for a broad range of applications from neutralization of infection to diagnosis. Why aptamers for these applications? For neutralization of… Leer más »Aptamers for virus infection , prevention and diagnosis
Why consider aptamers for therapeutic applications? There has only been one aptamer based therapeutic ever approved, Macugen (https://en.wikipedia.org/wiki/Pegaptanib) and the commercial sales for this treatment were not blockbuster… The biggest issue facing any therapeutic development effort is definitely the risk of failure, especially the risk… Leer más »Why Consider Aptamers for therapeutic Applications ?
We have succeeded in developing high affinity and high specificity aptamers for both the spike protein (S1) and the nucleoprotein from SARS-CoV-2 (COVID-19). These aptamers have been characterized and are available for purchase. We are working with several partners globally to apply these aptamers in… Leer más »NeoVentures Develops Aptamers for COVID-19
NeoVentures has successfully developed aptamers for both the spike protein and the nucleoprotein of SARS-CoV-2 (COVID-19). Spike protein aptamers were developed against a recombinant S1 protein from the Wuhan strain expressed in HEK293 cells in order to maintain appropriate glycosylation, counter selection was performed against… Leer más »Neo Ventures Announcement
Why are there not more aptamer based therapeutics? This blog by Drew Smith in 2019 nails a lot of the reasons, and in particular the issues related to the rapid clearance of aptamers from the body. https://drewsmithblog.com/2019/05/aptamers-still-looking-for-euphoria-in-the-wrong-places/. He effectively points out that the aptamer that… Leer más »Aptamers in therapeutics ? (Why not)
In a previous blog I stressed the need to further improve aptamer performance after SELEX identification in order to develop aptamers that are effective enough to be commercialized. I promised that I would describe how we do this at NeoVentures in more detail in a… Leer más »Optimized Aptamers II
In the ever-evolving field of diagnostics, precision and predictability are key to developing reliable products. However, the traditional reliance on antibodies poses significant challenges due to the inherent uncertainties in measuring their binding affinity and quantity. This creates a complex, two-variable problem that complicates product… Leer más »The Aptamer Advantage: Breaking Free from Antibody Uncertainty
For aptamers to be able to compete with antibodies in health care applications they need to perform as well as antibodies. At NeoVentures we have considered how antibodies evolve in response to an antigen and we have applied a similar approach to the optimization of… Leer más »Optimized Aptamers
In the rapidly evolving field of biotechnology, researchers constantly develop new tools and technologies to address pressing matters. One such technology that has been gaining significant attention is aptamers. These versatile, single-stranded DNA or RNA molecules have the unique ability to bind to specific targets.… Leer más »Advantages of Aptamers – Why You Should Know Aptamers!
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