{"id":2953,"date":"2022-08-25T13:11:24","date_gmt":"2022-08-25T17:11:24","guid":{"rendered":"https:\/\/neoaptamers.com\/?p=2953"},"modified":"2026-04-13T15:28:13","modified_gmt":"2026-04-13T19:28:13","slug":"what-is-aptamers","status":"publish","type":"post","link":"https:\/\/neoaptamers.com\/fr\/what-is-aptamers\/","title":{"rendered":"Qu'est-ce qu'un aptam\u00e8re ?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Trouver un r\u00e9actif de diagnostic adapt\u00e9 \u00e0 une application de point de soin peut \u00eatre d\u00e9licat en raison de la longue liste d'obstacles \u00e0 surmonter. Le r\u00e9actif doit \u00eatre stable sur \u00e9tag\u00e8re, fournir des r\u00e9sultats sensibles et s\u00e9lectifs de mani\u00e8re reproductible, \u00eatre facile \u00e0 synth\u00e9tiser et, plus important encore, \u00eatre peu co\u00fbteux. Pour de nombreux r\u00e9actifs de diagnostic actuellement sur le march\u00e9, tels que les anticorps, tous ces crit\u00e8res ne sont pas satisfaits, et c'est la cause principale de douleur pour les fournisseurs de kits de diagnostic. Les aptam\u00e8res cochent toutes les cases de cette liste.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3>Qu'est-ce qu'un aptam\u00e8re ?<\/h3>\n<p><span style=\"font-weight: 400;\">Les aptam\u00e8res sont de courtes mol\u00e9cules d'ADN ou d'ARN \u00e0 simple brin qui peuvent se lier de mani\u00e8re s\u00e9lective \u00e0 n'importe quelle cible \u00e0 laquelle elles sont con\u00e7ues pour se lier. Comme les aptam\u00e8res sont \u00e0 simple brin, ils peuvent adopter une vari\u00e9t\u00e9 de structures tridimensionnelles diff\u00e9rentes, telles que des boucles et des tiges. La grande vari\u00e9t\u00e9 de formes possibles permet aux aptam\u00e8res d'avoir une haute s\u00e9lectivit\u00e9 et sp\u00e9cificit\u00e9. Les aptam\u00e8res ne sont pas fabriqu\u00e9s dans des organismes vivants ; ils sont synth\u00e9tis\u00e9s sur un instrument. Cela signifie que nous avons une reproductibilit\u00e9 compl\u00e8te des performances de lot en lot de synth\u00e8se. \u00c9tant donn\u00e9 que la s\u00e9lection des aptam\u00e8res est effectu\u00e9e sur un banc de laboratoire et non \u00e0 l'int\u00e9rieur d'un animal, les cibles pour la liaison peuvent \u00eatre n'importe quoi, des cellules et de grandes biomol\u00e9cules jusqu'aux petites mol\u00e9cules qui ne seraient pas suffisamment antig\u00e9niques pour les anticorps.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-2934\" src=\"https:\/\/neoaptamers.com\/wp-content\/uploads\/2022\/08\/Screen-Shot-2022-08-22-at-3.55.36-PM.png\" alt=\"An aptamer binding to a target\" width=\"1252\" height=\"352\" srcset=\"https:\/\/neoaptamers.com\/wp-content\/uploads\/2022\/08\/Screen-Shot-2022-08-22-at-3.55.36-PM.png 1252w, https:\/\/neoaptamers.com\/wp-content\/uploads\/2022\/08\/Screen-Shot-2022-08-22-at-3.55.36-PM-300x84.png 300w, https:\/\/neoaptamers.com\/wp-content\/uploads\/2022\/08\/Screen-Shot-2022-08-22-at-3.55.36-PM-1024x288.png 1024w, https:\/\/neoaptamers.com\/wp-content\/uploads\/2022\/08\/Screen-Shot-2022-08-22-at-3.55.36-PM-768x216.png 768w\" sizes=\"(max-width: 1252px) 100vw, 1252px\" \/><\/p>\n<p>&nbsp;<\/p>\n<h3>Pourquoi les aptam\u00e8res ?<\/h3>\n<p><span style=\"font-weight: 400;\">L'utilisation des aptam\u00e8res dans la d\u00e9tection ou la s\u00e9lection de cibles existe depuis des d\u00e9cennies. La technologie pour rendre la conception d'aptam\u00e8res plus rapide et plus s\u00e9lective s'am\u00e9liore continuellement. Actuellement, nous avons la capacit\u00e9 de compl\u00e9ter un projet de s\u00e9lection et de livraison d'aptam\u00e8res en trois mois. Les aptam\u00e8res peuvent \u00eatre exp\u00e9di\u00e9s, stock\u00e9s et utilis\u00e9s \u00e0 diff\u00e9rentes temp\u00e9ratures, ce qui les rend plus fiables et robustes pour les tests diagnostiques que les anticorps. Les aptam\u00e8res se sont r\u00e9v\u00e9l\u00e9s \u00eatre des outils prometteurs non seulement dans le monde du diagnostic, mais \u00e9galement dans l'espace th\u00e9rapeutique o\u00f9 des m\u00e9dicaments peuvent leur \u00eatre attach\u00e9s afin de livrer des traitements \u00e0 des cellules sp\u00e9cifiques.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Chez NeoVentures, nous avons r\u00e9volutionn\u00e9 la s\u00e9lection des aptam\u00e8res et pouvons optimiser la structure pour augmenter l'affinit\u00e9 de liaison aux cibles. <a href=\"https:\/\/neoaptamers.com\/fr\/contact-us\/\">Pour en savoir plus, contactez notre \u00e9quipe d\u00e8s aujourd'hui.<\/a><\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Finding a diagnostic reagent that is right for a point-of-care application can be tricky due to the long list of obstacles that need to be overcome. The reagent needs to be shelf-stable, give reproducibly sensitive and selective results, be easy to synthesize, and most importantly, be inexpensive. For many diagnostic reagents on the market currently,&hellip;&nbsp;<a href=\"https:\/\/neoaptamers.com\/fr\/what-is-aptamers\/\" rel=\"bookmark\">Lire la suite &raquo;<span class=\"screen-reader-text\">Qu'est-ce qu'un aptam\u00e8re ?<\/span><\/a><\/p>","protected":false},"author":2,"featured_media":2932,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":70,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[8,30],"tags":[],"class_list":["post-2953","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aptamers","category-introductory"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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