{"id":1569,"date":"2021-09-29T05:17:36","date_gmt":"2021-09-29T09:17:36","guid":{"rendered":"https:\/\/neoaptamers.com\/?p=1569"},"modified":"2026-04-14T09:33:50","modified_gmt":"2026-04-14T13:33:50","slug":"the-advantage-of-shorter-aptamers","status":"publish","type":"post","link":"https:\/\/neoaptamers.com\/fr\/the-advantage-of-shorter-aptamers\/","title":{"rendered":"The Advantage of Shorter Aptamers"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"1569\" class=\"elementor elementor-1569\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ddd5134 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ddd5134\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-116a3e7\" data-id=\"116a3e7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-33ad19f elementor-widget elementor-widget-text-editor\" data-id=\"33ad19f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u201cA person is a person no matter how small\u201d Dr. Seuss in Horton\u2019s Hears a Who<\/p><p>I am not sure how well distributed Dr. Seuss books are outside of North America. They were a staple of my childhood, and I made sure that they were a staple of my children\u2019s childhood. I have also used this quote in the reverse sense, \u201cA person is a person, no matter how big\u201d when psyching myself for meetings with big companies. What does this have to do with aptamers? The length of an aptamer is not a function of its size but it\u2019s ability to bind to a target molecule.<\/p><p>We use 80 nucleotide sequences in our aptamer selection process, with a random region of 40 nucleotides. This is a good size for selection because the relatively large random region results in the majority of the secondary structure not being involved with the primer recognition sequences. An 80 nucleotide aptamer is not desirable for commercial application however.<\/p><ul><li>The extra nucleotides on a longer aptamer are not involved in the binding event and can reduce both the rate of complex formation by getting in the way, and the rate of complexes coming apart by reducing the stability of the aptamer structure.<\/li><li>In the synthesis process for an aptamer there is failure to appropriate add the next nucleotide approximately 0.8% of the time. The cost of aptamer synthesis is based on the cost of the components used to create it. The longer an aptamer is, the less actual aptamer you derive from the same amount of starting components<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4da47b7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4da47b7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e6abc35\" data-id=\"e6abc35\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b1f9d0 elementor-widget elementor-widget-image\" data-id=\"2b1f9d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"461\" src=\"https:\/\/neoaptamers.com\/wp-content\/uploads\/2021\/09\/zx1-768x461.png\" class=\"attachment-medium_large size-medium_large wp-image-1575\" alt=\"\" srcset=\"https:\/\/neoaptamers.com\/wp-content\/uploads\/2021\/09\/zx1-768x461.png 768w, https:\/\/neoaptamers.com\/wp-content\/uploads\/2021\/09\/zx1-300x180.png 300w, https:\/\/neoaptamers.com\/wp-content\/uploads\/2021\/09\/zx1-1024x614.png 1024w, https:\/\/neoaptamers.com\/wp-content\/uploads\/2021\/09\/zx1-1536x921.png 1536w, https:\/\/neoaptamers.com\/wp-content\/uploads\/2021\/09\/zx1-2048x1228.png 2048w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-300ae1d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"300ae1d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a8ed710\" data-id=\"a8ed710\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-44ee5bb elementor-widget elementor-widget-text-editor\" data-id=\"44ee5bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In the case of aptamers the optimum size is perhaps closer to Goldilocks than to Dr. Seuss, not larger or smaller than it needs to be.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u201cA person is a person no matter how small\u201d Dr. Seuss in Horton\u2019s Hears a Who I am not sure how well distributed Dr. Seuss books are outside of North America. They were a staple of my childhood, and I made sure that they were a staple of my children\u2019s childhood. I have also used&hellip;&nbsp;<a href=\"https:\/\/neoaptamers.com\/fr\/the-advantage-of-shorter-aptamers\/\" rel=\"bookmark\">Lire la suite &raquo;<span class=\"screen-reader-text\">The Advantage of Shorter Aptamers<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":1570,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":70,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[8],"tags":[],"class_list":["post-1569","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aptamers"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Advantage of Shorter Aptamers<\/title>\n<meta name=\"description\" content=\"The length of an aptamer is not a function of its size but it\u2019s ability to bind to a target molecule. Learn more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neoaptamers.com\/fr\/the-advantage-of-shorter-aptamers\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Advantage of Shorter Aptamers\" \/>\n<meta property=\"og:description\" content=\"The length of an aptamer is not a function of its size but it\u2019s ability to bind to a target molecule. 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