{"id":1476,"date":"2021-08-10T05:25:37","date_gmt":"2021-08-10T09:25:37","guid":{"rendered":"https:\/\/neoaptamers.com\/?p=1476"},"modified":"2026-04-14T09:55:13","modified_gmt":"2026-04-14T13:55:13","slug":"commercializing-aptamers-part-i-aptamer-rd","status":"publish","type":"post","link":"https:\/\/neoaptamers.com\/fr\/commercializing-aptamers-part-i-aptamer-rd\/","title":{"rendered":"Commercializing Aptamers Part I &#8211; Aptamer R&#038;D"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"1476\" class=\"elementor elementor-1476\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d513441 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d513441\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1ba2363\" data-id=\"1ba2363\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-df06c22 elementor-widget elementor-widget-text-editor\" data-id=\"df06c22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>When thinking of aptamer R&amp;D the following metaphor comes to mind. The first transcontinental railway in Canada had to make it through the rocky mountains. In the Kicking Horse Pass the grade was so steep that trains were at constant risk of derailing. This was solved with the introduction of a spiral tunnel through the mountain to reduce the grade. These spiral tunnels are still in use today.<\/p><p>I have often told clients that aptamer R&amp;D is like first seeing the mountains. It is exciting, we can watch the sun rise and set on the mountain, the snow accumulate in winter and melt in spring. But to commercialize an aptamer requires that we stop gazing at the mountain and actually climb over it. To discover a good aptamer is easy compared to succeeding in bringing it across the finish line of commercialization. We learned ourselves from scratch with our series of commercial aptamers for mycotoxin detection. It took us at least two years to move from discovering aptamers for ochratoxin A and aflatoxin B1 to develop these into commercial products.<\/p><p>Development of a commercial product requires a different set of problem solving skills than developing aptamers. Here is an overview of the problems to be faced.<\/p><h4>Problems Faced by Aptamer R&amp;D<\/h4><ul><li>Obtain the limit of detection required for commercial relevance<ol><li>Reduce noise, increase signal<\/li><li>Characterize specificity, and determine salt concentrations to maximize<\/li><\/ol><\/li><li>Characterize response over a relevant range of concentrations<ol><li>Is there a Hook effect? (high concentrations start to show low results)<\/li><li>Where does linearity of response start to fail<\/li><\/ol><\/li><li>Demonstrate reproducibility in your own lab<ol><li>Test different formulations of the same test<\/li><li>Test after storage for varying time periods<\/li><\/ol><\/li><li>Characterize and improve the robustness of the assay<ol><li>What can be varied, how much, and what components have to be carefully monitored<\/li><li>Write a detailed Standard Operating Procedure (SOP)<\/li><\/ol><\/li><li>Transfer the technology to another party and have them reproduce your results<ol><li>Figure out why they are not\u2026 and fix the problem<\/li><\/ol><\/li><li>Develop a prototype for commercial scale<ol><li>Optimize the balance between ease of use, cost of production and performance<\/li><\/ol><\/li><\/ul><p>After all of these steps you are ready for regulatory approval and commercial scaleup. The way I see this process is that there is a solution space but it is nested in a large space of problems. It is necessary to design development experiments so that will tell you what direction you need to go in to improve things further. Finding out what works and what does not work is a start but it is not sufficient.<\/p><p>Publishing a paper demonstrating the affinity and specificity of a new aptamer is great, but this is like seeing a mountain for the first time. Developing that aptamer into a commercial product involves planning the path up the mountain, learning to adapt or change your path based on cliffs that were steeper than anticipated or rocks that were looser than they looked. With each aptamer we develop we learn in excruciating detail about a specific mountain, but we also learn about mountains in general. Mountain climbing and commercial development of aptamers is difficult, but both are more rewarding than gazing at something beautiful.<\/p><p>Check out the next blog <a href=\"https:\/\/neoaptamers.com\/fr\/commercializing-aptamers-part-ii-first-commercial-aptamer\/\">here<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>When thinking of aptamer R&amp;D the following metaphor comes to mind. The first transcontinental railway in Canada had to make it through the rocky mountains. In the Kicking Horse Pass the grade was so steep that trains were at constant risk of derailing. This was solved with the introduction of a spiral tunnel through the&hellip;&nbsp;<a href=\"https:\/\/neoaptamers.com\/fr\/commercializing-aptamers-part-i-aptamer-rd\/\" rel=\"bookmark\">Lire la suite &raquo;<span class=\"screen-reader-text\">Commercializing Aptamers Part I &#8211; Aptamer R&#038;D<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":1482,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":70,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[8,11],"tags":[],"class_list":["post-1476","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aptamers","category-aptamers-in-diagnostics"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Commercializing Aptamers Part I - Aptamer R&amp;D<\/title>\n<meta name=\"description\" content=\"Learn why aptamer R&amp;D is like building a railway through the Rockies, and the specific steps needed to cross the finish line.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neoaptamers.com\/fr\/commercializing-aptamers-part-i-aptamer-rd\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Commercializing Aptamers Part I - Aptamer R&amp;D\" \/>\n<meta property=\"og:description\" content=\"Learn why aptamer R&amp;D is like building a railway through the Rockies, and the specific steps needed to cross the finish line.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/neoaptamers.com\/fr\/commercializing-aptamers-part-i-aptamer-rd\/\" \/>\n<meta property=\"og:site_name\" content=\"neoaptamers\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-10T09:25:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-14T13:55:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/neoaptamers.com\/wp-content\/uploads\/2021\/08\/kl1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"partyinfrance\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"partyinfrance\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/neoaptamers.com\\\/commercializing-aptamers-part-i-aptamer-rd\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/neoaptamers.com\\\/commercializing-aptamers-part-i-aptamer-rd\\\/\"},\"author\":{\"name\":\"partyinfrance\",\"@id\":\"https:\\\/\\\/neoaptamers.com\\\/#\\\/schema\\\/person\\\/34934951075d3d931c9216ed7f568fe6\"},\"headline\":\"Commercializing Aptamers Part I &#8211; 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