{"id":1207,"date":"2021-03-09T05:36:45","date_gmt":"2021-03-09T10:36:45","guid":{"rendered":"https:\/\/neoaptamers.com\/?p=1207"},"modified":"2026-04-14T10:22:20","modified_gmt":"2026-04-14T14:22:20","slug":"aptamers-for-therapeutics","status":"publish","type":"post","link":"https:\/\/neoaptamers.com\/fr\/aptamers-for-therapeutics\/","title":{"rendered":"Why Consider Aptamers for Therapeutic Applications?"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"1207\" class=\"elementor elementor-1207\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5a8acb0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5a8acb0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-dee6506\" data-id=\"dee6506\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8223f00 elementor-widget elementor-widget-text-editor\" data-id=\"8223f00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Why consider aptamers for therapeutic applications? There has only been one aptamer based therapeutic ever approved, Macugen <span style=\"color: #ff6600;\">(<a style=\"color: #ff6600;\" href=\"https:\/\/en.wikipedia.org\/wiki\/Pegaptanib\">https:\/\/en.wikipedia.org\/wiki\/Pegaptanib<\/a>)<\/span> and the commercial sales for this treatment were not blockbuster\u2026 The biggest issue facing any therapeutic development effort is definitely the risk of failure, especially the risk of failure late in development. So why should you consider aptamers when the success has been underwhelming to date?<\/p><p>There are actually several reasons.<\/p><ul><li>Aptamers are better now because of next generation sequence characterization and because of NeoVentures proprietary energy landscape optimization approach.<\/li><li>Aptamers will not cause an adverse immune response. Blood contains an abundance of oligonucleotides already.<\/li><li>Aptamers will be cleared through the renal system (pharmacokinetics are clear).<\/li><li>Aptamer structures are easily manipulated.<\/li><\/ul><p>This last point is I think actually the strongest of the four. When embarking on a therapeutic discovery project risk is reduced is you can work with a meaningful family of related therapeutic compounds. Given the identification of an aptamer that binds to your target of interest, it is trivial to create a family of aptamers with similar properties with simple nucleotide substitutions. In this way it is possible to dial up and down the level of effect of the therapeutic aptamer.<\/p><p>We are actively engaged in the use of molecular dynamics to model the structural interaction of aptamers with these targets. This is clearly the approach of the future for intelligent drug design and this will be achievable first with aptamers.<\/p><p>Aptamers have underwhelmed to date with therapeutic applications, but I would not bet against this underdog for the future. To discuss your potential application with experts at NeoVentures please <a href=\"https:\/\/neoaptamers.com\/fr\/contact-us\/\"><span style=\"color: #ff6600;\">contactez-nous<\/span><\/a> .<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Why consider aptamers for therapeutic applications? There has only been one aptamer based therapeutic ever approved, Macugen (https:\/\/en.wikipedia.org\/wiki\/Pegaptanib) and the commercial sales for this treatment were not blockbuster\u2026 The biggest issue facing any therapeutic development effort is definitely the risk of failure, especially the risk of failure late in development. So why should you consider&hellip;&nbsp;<a href=\"https:\/\/neoaptamers.com\/fr\/aptamers-for-therapeutics\/\" rel=\"bookmark\">Lire la suite &raquo;<span class=\"screen-reader-text\">Why Consider Aptamers for Therapeutic Applications?<\/span><\/a><\/p>","protected":false},"author":1,"featured_media":1208,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":70,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-1207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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